Direct Addition of Grignard Reagents to Aliphatic Carboxylic Acids Enabled by Bulky turbo ‐Organomagnesium Anilides

zu Verbundenen Objekten

Abstract: The synthesis of ketones through addition of organometallic reagents to aliphatic carboxylic acids is a straightforward strategy that is limited to organolithium reagents. More desirable Grignard reagents can be activated and controlled with a bulky aniline‐derived turbo‐Hauser base. This operationally simple procedure allows the straightforward preparation of a variety of aliphatic and perfluoroalkyl ketones alike from functionalized alkyl, aryl and heteroaryl Grignard reagents.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Direct Addition of Grignard Reagents to Aliphatic Carboxylic Acids Enabled by Bulky turbo ‐Organomagnesium Anilides ; day:27 ; month:01 ; year:2022 ; extent:1
Chemistry - a European journal ; (27.01.2022) (gesamt 1)

Urheber
Colas, Kilian
V. D. dos Santos, A. Catarina
Kohlhepp, Stefanie V.
Mendoza, Abraham

DOI
10.1002/chem.202104053
URN
urn:nbn:de:101:1-2022012714233945472499
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
15.08.2025, 07:31 MESZ

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Beteiligte

  • Colas, Kilian
  • V. D. dos Santos, A. Catarina
  • Kohlhepp, Stefanie V.
  • Mendoza, Abraham

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