Supramolecular complexes in cell death and inflammation and their regulation by autophagy

Abstract: Signaling activation is a tightly regulated process involving myriad posttranslational modifications such as phosphorylation/dephosphorylation, ubiquitylation/deubiquitylation, proteolytical cleavage events as well as translocation of proteins to new compartments within the cell. In addition to each of these events potentially regulating individual proteins, the assembly of very large supramolecular complexes has emerged as a common theme in signal transduction and is now known to regulate many signaling events. This is particularly evident in pathways regulating both inflammation and cell death/survival. Regulation of the assembly and silencing of these complexes plays important roles in immune signaling and inflammation and the fate of cells to either die or survive. Here we will give a summary of some of the better studied supramolecular complexes involved in inflammation and cell death, particularly with a focus on diseases caused by their autoactivation and the role autophagy either plays or may be playing in their regulation

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch
Anmerkungen
issn: 2296-634X

Klassifikation
Biowissenschaften, Biologie
Schlagwort
Entzündung
Zelltod
Angeborene Immunität
Autophagie

Ereignis
Veröffentlichung
(wo)
Freiburg
(wer)
Universität
(wann)
2019
Urheber

DOI
10.3389/fcell.2019.00073
URN
urn:nbn:de:bsz:25-freidok-1497337
Rechteinformation
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Letzte Aktualisierung
25.03.2025, 13:51 MEZ

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Beteiligte

Entstanden

  • 2019

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