Genotoxic effect of exposure to polycyclic aromatic hydrocarbons (PAHs) in asphalt workers

Abstract: Asphalt workers are at risk due to exposure to asphalt fumes containing polycyclic aromatic hydrocarbons (PAHs). The main purpose of this study was to measure the urinary metabolite of PAHs and to determine its effect on micronucleus (MN) formation as an indicator of genotoxic damage. In this cross-sectional study, the MN frequency in 48 male asphalt workers exposed to PAHs was measured and compared with 48 male non-exposed employees. PAHs exposure was evaluated by determining urinary 1-Hydroxypyrene (1-OHP). The mean concentrations of 1-OHP in the exposed and non-exposed groups were 0.58 ± 0.41 μmol/mol creatinine and 0.38 ± 0.25 μmol/mol creatinine, respectively. 1-OHP concentration was significantly higher in smokers compared with non-smokers in both exposed and non-exposed groups. Moreover, the mean MN frequency in the exposed group was significantly higher than in the non-exposed group. The MN frequency was significantly higher in asphalt workers with a work history of ≥ 15 ye.... https://www.excli.de/index.php/excli/article/view/3487

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Genotoxic effect of exposure to polycyclic aromatic hydrocarbons (PAHs) in asphalt workers ; volume:20 ; day:16 ; month:03 ; year:2021 ; EXCLI journal ; 20 (16.03.2021)

Contributors, Places and Time

• Creator: Kargar-Shouroki, Fatemeh ; Miri, Mohammad ; Zare Sakhvidi, Mohammad Javad ; Hosseini Sangchi, Seyedeh Zahra ; Madadizadeh, Farzan

Further information

• DOI: 10.17179/excli2021-3487
• URN: urn:nbn:de:101:1-2021051813411846740645
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:52 AM CEST