Self-organization of modular network architecture by activity-dependent neuronal migration and outgrowth
Abstract: The spatial distribution of neurons and activity-dependent neurite outgrowth shape long-range interaction, recurrent local connectivity and the modularity in neuronal networks. We investigated how this mesoscale architecture develops by interaction of neurite outgrowth, cell migration and activity in cultured networks of rat cortical neurons and show that simple rules can explain variations of network modularity. In contrast to theoretical studies on activity-dependent outgrowth but consistent with predictions for modular networks, spontaneous activity and the rate of synchronized bursts increased with clustering, whereas peak firing rates in bursts increased in highly interconnected homogeneous networks. As Ca2+ influx increased exponentially with increasing network recruitment during bursts, its modulation was highly correlated to peak firing rates. During network maturation, long-term estimates of Ca2+ influx showed convergence, even for highly different mesoscale architectures, neurite extent, connectivity, modularity and average activity levels, indicating homeostatic regulation towards a common set-point of Ca2+ influx
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Anmerkungen
-
eLife. - 8 (2019) , e47996, ISSN: 2050-084X
- Schlagwort
-
Netzwerk
Migration
Proteinkinase C
Neurowissenschaften
- Ereignis
-
Veröffentlichung
- (wo)
-
Freiburg
- (wer)
-
Universität
- (wann)
-
2020
- Urheber
- DOI
-
10.7554/eLife.47996
- URN
-
urn:nbn:de:bsz:25-freidok-1517043
- Rechteinformation
-
Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
14.08.2025, 10:50 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Okujeni, Samora
- Egert, Ulrich
- Universität
Entstanden
- 2020
Ähnliche Objekte (12)
Self-organization of modular activity in immature cortical networks
Guided self-organization : inception
Self-Organization and Society
Self-organization of Vectors
Self-Organization Through Semiosis
Multipotent Systems: Combining Planning, Self-Organization, and Reconfiguration in Modular Robot Ensembles
Self-organization in electrochemical systems, 1.. General principles of self-organization, temporal instabilities
Metarepresentation, self-organization and art
Self-organization and associative memory
Self-organization and associative memory
Self-organization and the city
Self-organization and social science
Self-organization of modular activity in immature cortical networks
Guided self-organization : inception
Self-Organization and Society
Self-organization of Vectors
Self-Organization Through Semiosis
Multipotent Systems: Combining Planning, Self-Organization, and Reconfiguration in Modular Robot Ensembles
Self-organization in electrochemical systems, 1.. General principles of self-organization, temporal instabilities
Metarepresentation, self-organization and art
Self-organization and associative memory
Self-organization and associative memory
Self-organization and the city
Self-organization and social science
Self-organization of modular activity in immature cortical networks
Guided self-organization : inception
Self-Organization and Society
Self-organization of Vectors
Self-Organization Through Semiosis
Multipotent Systems: Combining Planning, Self-Organization, and Reconfiguration in Modular Robot Ensembles
Self-organization in electrochemical systems, 1.. General principles of self-organization, temporal instabilities
Metarepresentation, self-organization and art
Self-organization and associative memory
Self-organization and associative memory
Self-organization and the city