Size‐Dependent Pulmonary Impact of Thin Graphene Oxide Sheets in Mice: Toward Safe‐by‐Design
Abstract: Safety assessment of graphene‐based materials (GBMs) including graphene oxide (GO) is essential for their safe use across many sectors of society. In particular, the link between specific material properties and biological effects needs to be further elucidated. Here, the effects of lateral dimensions of GO sheets in acute and chronic pulmonary responses after single intranasal instillation in mice are compared. Micrometer‐sized GO induces stronger pulmonary inflammation than nanometer‐sized GO, despite reduced translocation to the lungs. Genome‐wide RNA sequencing also reveals distinct size‐dependent effects of GO, in agreement with the histopathological results. Although large GO, but not the smallest GO, triggers the formation of granulomas that persists for up to 90 days, no pulmonary fibrosis is observed. These latter results can be partly explained by Raman imaging, which evidences the progressive biotransformation of GO into less graphitic structures. The findings demonstrate that lateral dimensions play a fundamental role in the pulmonary response to GO, and suggest that airborne exposure to micrometer‐sized GO should be avoided in the production plant or applications, where aerosolized dispersions are likely to occur. These results are important toward the implementation of a safer‐by‐design approach for GBM products and applications, for the benefit of workers and end‐users.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Size‐Dependent Pulmonary Impact of Thin Graphene Oxide Sheets in Mice: Toward Safe‐by‐Design ; volume:7 ; number:12 ; year:2020 ; extent:17
Advanced science ; 7, Heft 12 (2020) (gesamt 17)
- Creator
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Rodrigues, Artur Filipe
Newman, Leon
Jasim, Dhifaf
Mukherjee, Sourav P.
Wang, Jun
Vacchi, Isabella A.
Ménard‐Moyon, Cécilia
Bianco, Alberto
Fadeel, Bengt
Kostarelos, Kostas
Bussy, Cyrill
- DOI
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10.1002/advs.201903200
- URN
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urn:nbn:de:101:1-2022062310372401635659
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:24 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Rodrigues, Artur Filipe
- Newman, Leon
- Jasim, Dhifaf
- Mukherjee, Sourav P.
- Wang, Jun
- Vacchi, Isabella A.
- Ménard‐Moyon, Cécilia
- Bianco, Alberto
- Fadeel, Bengt
- Kostarelos, Kostas
- Bussy, Cyrill
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