Cooperative Chiral Lewis Base/Palladium‐Catalyzed Asymmetric Syntheses of Methylene‐Containing δ‐Lactams
Abstract: We herein report a two‐step approach for the enantioselective synthesis of novel chiral δ‐lactams. By using a cooperative chiral ITU/achiral Pd‐catalyst system, this protocol proceeds via an asymmetric α‐allylation of activated aryl esters first, followed by an acid‐mediated lactam formation. A variety of differently substituted products could be obtained with usually high levels of enantioselectivities and in reasonable yields (16 examples, up to 98: 2 er and 73 % yield over two steps). In addition, further utilizations of the products via transformations of the exocyclic double bond were successfully carried out as well.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Cooperative Chiral Lewis Base/Palladium‐Catalyzed Asymmetric Syntheses of Methylene‐Containing δ‐Lactams ; day:09 ; month:11 ; year:2023 ; extent:6
European journal of organic chemistry ; (09.11.2023) (gesamt 6)
- Urheber
- DOI
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10.1002/ejoc.202300982
- URN
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urn:nbn:de:101:1-2023111014050829473150
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:50 MESZ
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Beteiligte
- Zebrowski, Paul
- Monkowius, Uwe
- Waser, Mario
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