Angiotensin receptor blocker Losartan inhibits tumor growth of colorectal cancer

Abstract: The renin-angiotensin system (RAS) is up-regulated in patients with colorectal cancer (CRC) and is reported to be associated with poor prognosis and chemo-resistance. Here we explored the therapeutic potential of targeting RAS in CRC using Losartan, an angiotensin receptor blocker. An integrative-systems biology approach was used to explore a proteome-level dataset of a gene signature that is modulated by Losartan. The anti-proliferative activity of Losartan was evaluated using 2- and 3-dimensional cell culture models. A xenograft model of colon cancer was used to investigate tumor growth with Losartan alone and in combination with 5-FU followed by histological staining (Hematoxylin & Eosin and Masson trichrome staining), biochemical analyses, gene expression analyses by RT-PCR, western blot/IHC, or MMP Gelatin Zymography studies. Effects on cell cycle and cell death were assessed by flow cytometry. Losartan inhibited cell growth and suppressed cell cycle progression, causing an in.... https://www.excli.de/index.php/excli/article/view/3083

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Angiotensin receptor blocker Losartan inhibits tumor growth of colorectal cancer ; volume:20 ; day:01 ; month:03 ; year:2021 ; EXCLI journal ; 20 (01.03.2021)

Beteiligte, Orts- und Zeitangaben

• Urheber: Hashemzehi, Milad ; Rahmani, Farzad ; Khoshakhlagh, Mahdieh ; Avan, Amir ; Asgharzadeh, Fereshteh ; Barneh, Farnaz ; Moradi-Marjaneh, Reyhaneh ; Soleimani, Atena ; Fiuji, Hamid ; Ferns, Gordon A. ; Ryzhikov, Mikhail ; Jafari, Mohieddin ; Khazaei, Majid ; Hassanian, Seyed Mahdi

Weitere Informationen

• DOI: 10.17179/excli2020-3083
• URN: urn:nbn:de:101:1-2021051813392388233097
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 10:55 MESZ