Retinal thinning in adults with autism spectrum disorder

Abstract: Since the retina shares its embryological origin with the central nervous system, optical coherence tomography (OCT), an imaging technique frequently employed in ophthalmology to analyze the macula and intraretinal layer thicknesses and volumes, has recently become increasingly important in psychiatric research. We examined 34 autistic and 31 neurotypical adults (NT) using OCT. Autistic adults had reduced overall macular and outer nuclear layer (ONL) thickness and volume compared to NT. Both macular and ONL thickness showed significant inverse associations with the severity of autistic symptoms measured with the Social Responsiveness Scale 2 (SRS-2). Longitudinal studies across different age groups are required to clarify whether retinal changes may represent a possible trait marker

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch
• Notes: Journal of autism and developmental disorders. - 54, 3 (2024) , 1143-1156, ISSN: 1573-3432

Contributors, Places and Time

• Event: Veröffentlichung
• (where): Freiburg
• (who): Universität
• (when): 2023
• Creator: Friedel, Evelyn ; Tebartz van Elst, Ludger ; Schäfer, Mirjam ; Maier, Simon ; Runge, Kimon ; Küchlin, Sebastian ; Reich, Michael ; Lagrèze, Wolf A. ; Kornmeier, Jürgen ; Ebert, Dieter ; Endres, Dominique ; Domschke, Katharina ; Nickel, Kathrin Alexandra

Further information

• DOI: 10.1007/s10803-022-05882-8
• URN: urn:nbn:de:bsz:25-freidok-2324344
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 25.03.2025, 1:46 PM CET