Phytotherapeutic Hierarchical PCL‐Based Scaffolds as a Multifunctional Wound Dressing: Combining 3D Printing and Electrospinning
Abstract: This study focuses on developing hybrid scaffolds incorporating phytotherapeutic agents via a combination of three‐dimensional (3D) printing and electrospinning to enhance mechanical properties and provide antibacterial activity, in order to address the limitations of traditional antibiotics. In this regard, 3D‐printed polycaprolactone (PCL) struts are first fabricated using fused deposition modeling (FDM). Then, alkaline surface treatment is applied to improve the adhesion of electrospun nanofibers. Finally, peppermint oil (PEP) or clove oil (CLV)‐incorporated PCL‐gelatin (GEL) electrospun nanofibers are collected on top of the 3D‐printed PCL scaffolds by electrospinning. Incorporating PEP or CLV into PCL‐GEL electrospun nanofibers enhances the scaffold's layer detachment and adhesion force. In addition, the DPPH free radical scavenging activity assay indicates that incorporating PEP or CLV improves the antioxidant properties of the scaffolds. Further, antibacterial activity results reveal that PEP or CLV incorporated scaffolds exhibit inhibition against Staphylococcus aureus and Escherichia coli bacteria. Moreover, anti‐inflammatory assays show that scaffolds reduce the concentration of nitric oxide (NO) released from Raw 264.7 macrophage‐like cells. On the other hand, the phytotherapeutic hierarchical scaffolds have no toxic effect on normal human dermal fibroblast (NHDF) cells, and PEP or CLV enhance cell attachment and proliferation. Overall, incorporating natural phytotherapeutic agents into hierarchical scaffolds shows promise for advancing wound healing applications.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Phytotherapeutic Hierarchical PCL‐Based Scaffolds as a Multifunctional Wound Dressing: Combining 3D Printing and Electrospinning ; day:10 ; month:09 ; year:2024 ; extent:18
Macromolecular bioscience ; (10.09.2024) (gesamt 18)
- Creator
- DOI
-
10.1002/mabi.202400253
- URN
-
urn:nbn:de:101:1-2409111410576.314906115291
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:34 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Unalan, Irem
- Slavik, Benedikt
- Büttner, Andrea
- Boccaccini, Aldo R.
Other Objects (12)
Phytotherapeutic Hierarchical PCL‐Based Scaffolds as a Multifunctional Wound Dressing: Combining 3D Printing and Electrospinning
Versatile Production of Poly(Epsilon-Caprolactone) Fibers by Electrospinning Using Benign Solvents
Surface Modification of Bioactive Glass Scaffolds
Electrospinning with benign solvents: feasibility study and versatile use of poly(epsilon-caprolactone) fibers
Natural marine derived bioactive glass based scaffolds with improved functionalities
Development of multifunctional wound dressings by using newly designed ion doped borosilicate and borate bioactive glasses
Surface Modification of 3D-Printed PCL/BG Composite Scaffolds via Mussel-Inspired Polydopamine and Effective Antibacterial Coatings for Biomedical Applications
Collagen as Coating Material for 45S5 Bioactive Glass-Based Scaffolds for Bone Tissue Engineering
45S5 Bioactive Glass-Based Composite Scaffolds with Polymer Coatings for Bone Tissue Engineering Therapeutics
3D Printing of Mechanically Resistant Poly (Glycerol Sebacate) (PGS)‐Zein Scaffolds for Potential Cardiac Tissue Engineering Applications
Zur Abhängigkeit der mechanischen Eigenschaften zweiphasiger und poröser Werkstoffe von der Gefüge- bzw. Porositätsstruktur
Enzymatic Insitu Crosslinking Can Improve Hydrogel Stability While Maintaining Matrix Stiffness
Phytotherapeutic Hierarchical PCL‐Based Scaffolds as a Multifunctional Wound Dressing: Combining 3D Printing and Electrospinning
Versatile Production of Poly(Epsilon-Caprolactone) Fibers by Electrospinning Using Benign Solvents
Surface Modification of Bioactive Glass Scaffolds
Electrospinning with benign solvents: feasibility study and versatile use of poly(epsilon-caprolactone) fibers
Natural marine derived bioactive glass based scaffolds with improved functionalities
Development of multifunctional wound dressings by using newly designed ion doped borosilicate and borate bioactive glasses
Surface Modification of 3D-Printed PCL/BG Composite Scaffolds via Mussel-Inspired Polydopamine and Effective Antibacterial Coatings for Biomedical Applications
Collagen as Coating Material for 45S5 Bioactive Glass-Based Scaffolds for Bone Tissue Engineering
45S5 Bioactive Glass-Based Composite Scaffolds with Polymer Coatings for Bone Tissue Engineering Therapeutics
3D Printing of Mechanically Resistant Poly (Glycerol Sebacate) (PGS)‐Zein Scaffolds for Potential Cardiac Tissue Engineering Applications
Zur Abhängigkeit der mechanischen Eigenschaften zweiphasiger und poröser Werkstoffe von der Gefüge- bzw. Porositätsstruktur
Enzymatic Insitu Crosslinking Can Improve Hydrogel Stability While Maintaining Matrix Stiffness
Phytotherapeutic Hierarchical PCL‐Based Scaffolds as a Multifunctional Wound Dressing: Combining 3D Printing and Electrospinning
Versatile Production of Poly(Epsilon-Caprolactone) Fibers by Electrospinning Using Benign Solvents
Surface Modification of Bioactive Glass Scaffolds
Electrospinning with benign solvents: feasibility study and versatile use of poly(epsilon-caprolactone) fibers
Natural marine derived bioactive glass based scaffolds with improved functionalities
Development of multifunctional wound dressings by using newly designed ion doped borosilicate and borate bioactive glasses
Surface Modification of 3D-Printed PCL/BG Composite Scaffolds via Mussel-Inspired Polydopamine and Effective Antibacterial Coatings for Biomedical Applications
Collagen as Coating Material for 45S5 Bioactive Glass-Based Scaffolds for Bone Tissue Engineering
45S5 Bioactive Glass-Based Composite Scaffolds with Polymer Coatings for Bone Tissue Engineering Therapeutics
3D Printing of Mechanically Resistant Poly (Glycerol Sebacate) (PGS)‐Zein Scaffolds for Potential Cardiac Tissue Engineering Applications
Zur Abhängigkeit der mechanischen Eigenschaften zweiphasiger und poröser Werkstoffe von der Gefüge- bzw. Porositätsstruktur