Acute drug transfer and particle release of drug coated balloons within a porcine in-vitro model
Abstract: Drug coated balloons (DCB) are used in the therapy of coronary as well as peripheral artery disease. The success of drug transfer to the vessel wall depends on the excipient used in combination with paclitaxel as antiproliferative drug. Although in-vivo studies show very good results with this technology, there is a lack of in-vitro test methods for characterization of various DCB available on the market. This study describes a method to gain information about the drug transfer and the particle release of three different DCB based on cetylpyridinium salycate (Cetpyrsal), hyaluronic acid and iopromide within a porcine in-vitro model. The Cetpyrsal-based DCB showed promising results with the highest drug transfer while producing the lowest number of particles.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Acute drug transfer and particle release of drug coated balloons within a porcine in-vitro model ; volume:3 ; number:2 ; year:2017 ; pages:465-468 ; extent:4
Current directions in biomedical engineering ; 3, Heft 2 (2017), 465-468 (gesamt 4)
- Urheber
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Brandt-Wunderlich, Christoph
Almstädt, Lucas
Kaule, Sebastian
Reske, Thomas
Schmidt, Wolfram
Schmitz, Klaus-Peter
Grabow, Niels
- DOI
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10.1515/cdbme-2017-0098
- URN
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urn:nbn:de:101:1-2023030713140124070526
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:54 MESZ
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Beteiligte
- Brandt-Wunderlich, Christoph
- Almstädt, Lucas
- Kaule, Sebastian
- Reske, Thomas
- Schmidt, Wolfram
- Schmitz, Klaus-Peter
- Grabow, Niels
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