Systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer
Abstract: We performed a prospective study of circulating immune cell changes after stereotactic body radiotherapy (SBRT) in 50 early-stage NSCLC patients. We found no significant increase in CD8+ cytotoxic T lymphocytes at first follow-up (the primary endpoint) but detected a significant increase in expanding Ki-67+CD8+ and Ki-67+CD4+ T-cell fractions in patients treated with 10 Gy or less per fraction. SBRT can induce significant expansion in circulating effector T-cells immediately post-treatment
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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npj precision oncology. - 7, 1 (2023) , 24, ISSN: 2397-768X
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
-
Universität
- (when)
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2023
- Creator
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Gkika, Eleni
Firat, Elke
Adebahr, Sonja
Graf, Erika
Popp, Ilinca
Radicioni, Gianluca
Lo, Simon S.
Nestle, Ursula
Nicolay, Nils
Niedermann, Gabriele
Duda, Dan G.
Grosu, Anca-Ligia
- DOI
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10.1038/s41698-023-00358-z
- URN
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urn:nbn:de:bsz:25-freidok-2343934
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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25.03.2025, 1:47 PM CET
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Gkika, Eleni
- Firat, Elke
- Adebahr, Sonja
- Graf, Erika
- Popp, Ilinca
- Radicioni, Gianluca
- Lo, Simon S.
- Nestle, Ursula
- Nicolay, Nils
- Niedermann, Gabriele
- Duda, Dan G.
- Grosu, Anca-Ligia
- Universität
Time of origin
- 2023
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