The particle radiobiology of multipotent mesenchymal stromal cells: a key to mitigating radiation-induced tissue toxicities in cancer treatment and beyond?
Abstract: Mesenchymal stromal cells (MSCs) comprise a heterogeneous population of multipotent stromal cells that have gained attention for the treatment of irradiation-induced normal tissue toxicities due to their regenerative abilities. As the vast majority of studies focused on the effects of MSCs for photon irradiation-induced toxicities, little is known about the regenerative abilities of MSCs for particle irradiation-induced tissue damage or the effects of particle irradiation on the stem cell characteristics of MSCs themselves. MSC-based therapies may help treat particle irradiation-related tissue lesions in the context of cancer radiotherapy. As the number of clinical proton therapy centers is increasing, there is a need to decidedly investigate MSC-based treatments for particle irradiation-induced sequelae. Furthermore, therapies with MSCs or MSC-derived exosomes may also become a useful tool for manned space exploration or after radiation accidents and nuclear terrorism. However, such treatments require an in-depth knowledge about the effects of particle radiation on MSCs and the effects of MSCs on particle radiation-injured tissues. Here, the existing body of evidence regarding the particle radiobiology of MSCs as well as regarding MSC-based treatments for some typical particle irradiation-induced toxicities is presented and critically discussed
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Notes
-
Frontiers in oncology. - 11 (2021) , 616831, ISSN: 2234-943X
- Event
-
Veröffentlichung
- (where)
-
Freiburg
- (who)
-
Universität
- (when)
-
2021
- DOI
-
10.3389/fonc.2021.616831
- URN
-
urn:nbn:de:bsz:25-freidok-2185488
- Rights
-
Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
14.08.2025, 10:50 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Rühle, Alexander
- Grosu, Anca-Ligia
- Nicolay, Nils
- Universität
Time of origin
- 2021
Other Objects (12)
Aggressive Deeskalation der Strahlentherapie bei HPV-assoziierten Oropharynxkarzinomen auf der Basis der Hypoxiedynamik
Zirkulierende HPV-Tumor-DNA als möglicher Biomarker in der Rezidivdiagnostik des HPV-assoziierten Oropharynxkarzinoms
Aggressive Deeskalation der Strahlentherapie bei HPV-assoziierten Oropharynxkarzinomen auf der Basis der Hypoxiedynamik
Moderate Dosisdeeskalation der definitiven Cisplatin-basierten Radiochemotherapie für HPV-positive Oropharynxkarzinompatienten : : Ergebnisse der NRG-HN002-Studie = Moderate dose de-escalation of cisplatin-based chemoradiation for HPV-associated oropharyngeal carcinoma : results of the NRG-HN002 trial
Deeskalation der adjuvanten Radiotherapie nach transoraler Resektion HPV-positiver Oropharynxkarzinome: Ergebnisse der E3311-Studie : = De-escalation of adjuvant radiotherapy after transoral surgery of HPV-associated oropharyngeal cancer: results of the E3311 trial
Wöchentliche versus dreiwöchentliche Cisplatingabe bei der postoperativen Radiochemotherapie von lokal fortgeschrittenen Kopf-Hals-Plattenepithelkarzinomen – Ergebnisse der JCOG1008-Studie : = Weekly versus three-weekly cisplatin for the postoperative chemoradiation of locally advanced head-and-neck squamous cell carcinoma: results of the JCOG1008 trial
Wöchentliche versus dreiwöchentliche Cisplatingabe bei der postoperativen Radiochemotherapie von lokal fortgeschrittenen Kopf-Hals-Plattenepithelkarzinomen – Ergebnisse der JCOG1008-Studie
De-Escalation Strategies of (Chemo)Radiation for Head-and-Neck Squamous Cell Cancers—HPV and Beyond
Authors’ response to the Letter to the Editor by Efsun Somay and Erkan Topkan regarding our study “The influence of antibiotic administration on the outcomes of head-and-neck squamous cell carcinoma patients undergoing definitive (chemo)radiation”
Authors’ response to the letter to the editor by Busra Yilmaz and Ugur Selek regarding our study “The influence of antibiotic administration on the outcomes of head-and-neck squamous cell carcinoma patients undergoing definitive (chemo)radiation”
Predicting cisplatin tolerability in older adults with head and neck cancer – insights for improved chemoradiation outcomes
Essays on the effects of partitioned pricing strategies and branding decisions on consumer behavior
Aggressive Deeskalation der Strahlentherapie bei HPV-assoziierten Oropharynxkarzinomen auf der Basis der Hypoxiedynamik
Zirkulierende HPV-Tumor-DNA als möglicher Biomarker in der Rezidivdiagnostik des HPV-assoziierten Oropharynxkarzinoms
Aggressive Deeskalation der Strahlentherapie bei HPV-assoziierten Oropharynxkarzinomen auf der Basis der Hypoxiedynamik
Moderate Dosisdeeskalation der definitiven Cisplatin-basierten Radiochemotherapie für HPV-positive Oropharynxkarzinompatienten : : Ergebnisse der NRG-HN002-Studie = Moderate dose de-escalation of cisplatin-based chemoradiation for HPV-associated oropharyngeal carcinoma : results of the NRG-HN002 trial
Deeskalation der adjuvanten Radiotherapie nach transoraler Resektion HPV-positiver Oropharynxkarzinome: Ergebnisse der E3311-Studie : = De-escalation of adjuvant radiotherapy after transoral surgery of HPV-associated oropharyngeal cancer: results of the E3311 trial
Wöchentliche versus dreiwöchentliche Cisplatingabe bei der postoperativen Radiochemotherapie von lokal fortgeschrittenen Kopf-Hals-Plattenepithelkarzinomen – Ergebnisse der JCOG1008-Studie : = Weekly versus three-weekly cisplatin for the postoperative chemoradiation of locally advanced head-and-neck squamous cell carcinoma: results of the JCOG1008 trial
Wöchentliche versus dreiwöchentliche Cisplatingabe bei der postoperativen Radiochemotherapie von lokal fortgeschrittenen Kopf-Hals-Plattenepithelkarzinomen – Ergebnisse der JCOG1008-Studie
De-Escalation Strategies of (Chemo)Radiation for Head-and-Neck Squamous Cell Cancers—HPV and Beyond
Authors’ response to the Letter to the Editor by Efsun Somay and Erkan Topkan regarding our study “The influence of antibiotic administration on the outcomes of head-and-neck squamous cell carcinoma patients undergoing definitive (chemo)radiation”
Authors’ response to the letter to the editor by Busra Yilmaz and Ugur Selek regarding our study “The influence of antibiotic administration on the outcomes of head-and-neck squamous cell carcinoma patients undergoing definitive (chemo)radiation”
Predicting cisplatin tolerability in older adults with head and neck cancer – insights for improved chemoradiation outcomes
Essays on the effects of partitioned pricing strategies and branding decisions on consumer behavior
Aggressive Deeskalation der Strahlentherapie bei HPV-assoziierten Oropharynxkarzinomen auf der Basis der Hypoxiedynamik
Zirkulierende HPV-Tumor-DNA als möglicher Biomarker in der Rezidivdiagnostik des HPV-assoziierten Oropharynxkarzinoms
Aggressive Deeskalation der Strahlentherapie bei HPV-assoziierten Oropharynxkarzinomen auf der Basis der Hypoxiedynamik
Moderate Dosisdeeskalation der definitiven Cisplatin-basierten Radiochemotherapie für HPV-positive Oropharynxkarzinompatienten : : Ergebnisse der NRG-HN002-Studie = Moderate dose de-escalation of cisplatin-based chemoradiation for HPV-associated oropharyngeal carcinoma : results of the NRG-HN002 trial
Deeskalation der adjuvanten Radiotherapie nach transoraler Resektion HPV-positiver Oropharynxkarzinome: Ergebnisse der E3311-Studie : = De-escalation of adjuvant radiotherapy after transoral surgery of HPV-associated oropharyngeal cancer: results of the E3311 trial
Wöchentliche versus dreiwöchentliche Cisplatingabe bei der postoperativen Radiochemotherapie von lokal fortgeschrittenen Kopf-Hals-Plattenepithelkarzinomen – Ergebnisse der JCOG1008-Studie : = Weekly versus three-weekly cisplatin for the postoperative chemoradiation of locally advanced head-and-neck squamous cell carcinoma: results of the JCOG1008 trial
Wöchentliche versus dreiwöchentliche Cisplatingabe bei der postoperativen Radiochemotherapie von lokal fortgeschrittenen Kopf-Hals-Plattenepithelkarzinomen – Ergebnisse der JCOG1008-Studie
De-Escalation Strategies of (Chemo)Radiation for Head-and-Neck Squamous Cell Cancers—HPV and Beyond
Authors’ response to the Letter to the Editor by Efsun Somay and Erkan Topkan regarding our study “The influence of antibiotic administration on the outcomes of head-and-neck squamous cell carcinoma patients undergoing definitive (chemo)radiation”
Authors’ response to the letter to the editor by Busra Yilmaz and Ugur Selek regarding our study “The influence of antibiotic administration on the outcomes of head-and-neck squamous cell carcinoma patients undergoing definitive (chemo)radiation”
Predicting cisplatin tolerability in older adults with head and neck cancer – insights for improved chemoradiation outcomes