Systemic immune modulation by stereotactic radiotherapy in early-stage lung cancer
Abstract: We performed a prospective study of circulating immune cell changes after stereotactic body radiotherapy (SBRT) in 50 early-stage NSCLC patients. We found no significant increase in CD8+ cytotoxic T lymphocytes at first follow-up (the primary endpoint) but detected a significant increase in expanding Ki-67+CD8+ and Ki-67+CD4+ T-cell fractions in patients treated with 10 Gy or less per fraction. SBRT can induce significant expansion in circulating effector T-cells immediately post-treatment
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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npj precision oncology. - 7, 1 (2023) , 24, ISSN: 2397-768X
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
-
Universität
- (wann)
-
2023
- Urheber
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Gkika, Eleni
Firat, Elke
Adebahr, Sonja
Graf, Erika
Popp, Ilinca
Radicioni, Gianluca
Lo, Simon S.
Nestle, Ursula
Nicolay, Nils
Niedermann, Gabriele
Duda, Dan G.
Grosu, Anca-Ligia
- DOI
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10.1038/s41698-023-00358-z
- URN
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urn:nbn:de:bsz:25-freidok-2343934
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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25.03.2025, 13:47 MEZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
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Beteiligte
- Gkika, Eleni
- Firat, Elke
- Adebahr, Sonja
- Graf, Erika
- Popp, Ilinca
- Radicioni, Gianluca
- Lo, Simon S.
- Nestle, Ursula
- Nicolay, Nils
- Niedermann, Gabriele
- Duda, Dan G.
- Grosu, Anca-Ligia
- Universität
Entstanden
- 2023
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