Recent Progress of Potentiating Immune Checkpoint Blockade with External Stimuli—an Industry Perspective
Abstract: The past decade has seen the materialization of immune checkpoint blockade as an emerging approach to cancer treatment. However, the overall response and patient survival are still modest. Various efforts to study the “cancer immunogram” have highlighted complex biology that necessitates a multipronged approach. This includes increasing the antigenicity of the tumor, strengthening the immune infiltration in the tumor microenvironment, removing the immunosuppressive mechanisms, and reducing immune cell exhaustion. The coordination of these approaches, as well as the ability to enhance them through delivery, is evaluated. Due to their success in multiple preclinical models, external‐stimuli‐responsive nanoparticles have received tremendous attention. Several studies report success in distantly located tumor regression, metastases, and reoccurrence in preclinical mouse models. However, clinical translation in this space remains low. Herein, the recent advancement in external‐stimuli‐responsive nanoconstruct‐synergized immune checkpoint blockade is summarized, offering an industry perspective on the limitations of current academic innovations and discussing challenges in translation from a technical, manufacturing, and regulatory perspective. These limitations and challenges will need to be addressed to establish external‐stimuli‐based therapeutic strategies for patients.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Recent Progress of Potentiating Immune Checkpoint Blockade with External Stimuli—an Industry Perspective ; volume:7 ; number:8 ; year:2020 ; extent:18
Advanced science ; 7, Heft 8 (2020) (gesamt 18)
- Creator
-
Xu, Jun
Saklatvala, Robert
Mittal, Sachin
Deshmukh, Smeet
Procopio, Adam
- DOI
-
10.1002/advs.201903394
- URN
-
urn:nbn:de:101:1-2022062613444979305779
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:33 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Xu, Jun
- Saklatvala, Robert
- Mittal, Sachin
- Deshmukh, Smeet
- Procopio, Adam
Other Objects (12)
Untersuchung der Funkenzündung mittels 2D-laserinduzierter Fluoreszenz (LIF) von OH-Radikalen
A textile fabric protruding fibers measurement system based on camera vision and variable homography
Charakterisierung von MOVPE-II-VI-Halbleiter-Schichten mittels Röntgendiffraktometrie
Carbon Binder Domain Inhomogeneity in Silicon‐Monoxide/Graphite Composite Anode by 2D Multiphysics Modeling
Impedance Inhomogeneity in SiO/Gr Composite Anode
Geological characteristics of shale in the Silurian (Sichuan) basin and chemical reaction of its reservoir under the action of fracturing fluid
A 10-year follow up of publishing ethics in China: what is new and what is unchanged
New achievements in superlubricity from international workshop on superlubricity: fundamental and applications
Heterogeneous Reinforcements to Mitigate Li Penetration through Solid Electrolytes in All‐Solid‐State Batteries
Bridging the translation gap and building the translation platform: translational medicine at Peking Union Medical College Hospital
What does H7N9 mean and how can we be prepared for the next flu pandemic?
Timing of vasopressin initiation and mortality in patients with septic shock: analysis of the MIMIC-III and MIMIC-IV databases
Untersuchung der Funkenzündung mittels 2D-laserinduzierter Fluoreszenz (LIF) von OH-Radikalen
A textile fabric protruding fibers measurement system based on camera vision and variable homography
Charakterisierung von MOVPE-II-VI-Halbleiter-Schichten mittels Röntgendiffraktometrie
Carbon Binder Domain Inhomogeneity in Silicon‐Monoxide/Graphite Composite Anode by 2D Multiphysics Modeling
Impedance Inhomogeneity in SiO/Gr Composite Anode
Geological characteristics of shale in the Silurian (Sichuan) basin and chemical reaction of its reservoir under the action of fracturing fluid
A 10-year follow up of publishing ethics in China: what is new and what is unchanged
New achievements in superlubricity from international workshop on superlubricity: fundamental and applications
Heterogeneous Reinforcements to Mitigate Li Penetration through Solid Electrolytes in All‐Solid‐State Batteries
Bridging the translation gap and building the translation platform: translational medicine at Peking Union Medical College Hospital
What does H7N9 mean and how can we be prepared for the next flu pandemic?
Timing of vasopressin initiation and mortality in patients with septic shock: analysis of the MIMIC-III and MIMIC-IV databases
Untersuchung der Funkenzündung mittels 2D-laserinduzierter Fluoreszenz (LIF) von OH-Radikalen
A textile fabric protruding fibers measurement system based on camera vision and variable homography
Charakterisierung von MOVPE-II-VI-Halbleiter-Schichten mittels Röntgendiffraktometrie
Carbon Binder Domain Inhomogeneity in Silicon‐Monoxide/Graphite Composite Anode by 2D Multiphysics Modeling
Impedance Inhomogeneity in SiO/Gr Composite Anode
Geological characteristics of shale in the Silurian (Sichuan) basin and chemical reaction of its reservoir under the action of fracturing fluid
A 10-year follow up of publishing ethics in China: what is new and what is unchanged
New achievements in superlubricity from international workshop on superlubricity: fundamental and applications
Heterogeneous Reinforcements to Mitigate Li Penetration through Solid Electrolytes in All‐Solid‐State Batteries
Bridging the translation gap and building the translation platform: translational medicine at Peking Union Medical College Hospital
What does H7N9 mean and how can we be prepared for the next flu pandemic?