The neurovascular unit in diffuse intrinsic pontine gliomas

Abstract: Aims: Diffuse intrinsic pontine glioma (DIPG) is a childhood brainstem tumor with a median overall survival of eleven months. Lack of chemotherapy efficacy may be related to an intact blood-brain barrier (BBB). In this study we aim to investigate the neurovascular unit (NVU) in DIPG patients. Methods: DIPG biopsy (n = 4) and autopsy samples (n = 6) and age-matched healthy pons samples (n = 20) were immunohistochemically investigated for plasma protein extravasation, and the expression of tight junction proteins claudin-5 and zonula occludens-1 (ZO-1), basement membrane component laminin, pericyte marker PDGFR-β, and efflux transporters P-gp and BCRP. The mean vascular density and diameter were also assessed. Results: DIPGs show a heterogeneity in cell morphology and evidence of BBB leakage. Both in tumor biopsy and autopsy samples, expression of claudin-5, ZO-1, laminin, PDGFR-β and P-gp was reduced compared to healthy pontine tissues. In DIPG autopsy samples, vascular den.... https://www.uni-muenster.de/Ejournals/index.php/fnp/article/view/3341

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: The neurovascular unit in diffuse intrinsic pontine gliomas ; volume:2 ; day:05 ; month:07 ; year:2021 ; Free Neuropathology ; 2 (05.07.2021)

Contributors, Places and Time

• Creator: El-Khouly, Fatma E. ; Haumann, Rianne ; Breur, Marjolein ; Veldhuijzen van Zanten, Sophie E.M ; Kaspers, Gertjan J.L ; Hendrikse, N. Harry ; Hulleman, Esther ; van Vuurden, Dannis G. ; Bugiani, Marianna

Further information

• URN: urn:nbn:de:hbz:6:3-freeneuropathology-2021-34408
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:28 AM CEST