Functionalized Macrophage Exosomes with Panobinostat and PPM1D‐siRNA for Diffuse Intrinsic Pontine Gliomas Therapy
Abstract: Diffuse intrinsic pontine glioma (DIPG) is a rare and fatal pediatric brain tumor. Mutation of p53‐induced protein phosphatase 1 (PPM1D) in DIPG cells promotes tumor cell proliferation, and inhibition of PPM1D expression in DIPG cells with PPM1D mutation effectively reduces the proliferation activity of tumor cells. Panobinostat effectively kills DIPG tumor cells, but its systemic toxicity and low blood–brain barrier (BBB) permeability limits its application. In this paper, a nano drug delivery system based on functionalized macrophage exosomes with panobinostat and PPM1D‐siRNA for targeted therapy of DIPG with PPM1D mutation is prepared. The nano drug delivery system has higher drug delivery efficiency and better therapeutic effect than free drugs. In vivo and in vitro experimental results show that the nano drug delivery system can deliver panobinostat and siRNA across the BBB and achieve a targeted killing effect of DIPG tumor cells, resulting in the prolonged survival of orthotopic DIPG mice. This study provides new ideas for the delivery of small molecule drugs and gene drugs for DIPG therapy.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Functionalized Macrophage Exosomes with Panobinostat and PPM1D‐siRNA for Diffuse Intrinsic Pontine Gliomas Therapy ; day:18 ; month:05 ; year:2022 ; extent:14
Advanced science ; (18.05.2022) (gesamt 14)
- Urheber
-
Shan, Shaobo
Chen, Junge
Sun, Yu
Wang, Yongchao
Xia, Bozhang
Tan, Hong
Pan, Changcun
Gu, Guocan
Zhong, Jie
Qing, Guangchao
Zhang, Yuxuan
Wang, Jinjin
Wang, Yufei
Wang, Yi
Zuo, Pengcheng
Xu, Cheng
Li, Fangzhou
Guo, Weisheng
Xu, Lijun
Chen, Meiwan
Fan, Yubo
Zhang, Liwei
Liang, Xing‐Jie
- DOI
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10.1002/advs.202200353
- URN
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urn:nbn:de:101:1-2022051915200268776145
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:31 MESZ
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Beteiligte
- Shan, Shaobo
- Chen, Junge
- Sun, Yu
- Wang, Yongchao
- Xia, Bozhang
- Tan, Hong
- Pan, Changcun
- Gu, Guocan
- Zhong, Jie
- Qing, Guangchao
- Zhang, Yuxuan
- Wang, Jinjin
- Wang, Yufei
- Wang, Yi
- Zuo, Pengcheng
- Xu, Cheng
- Li, Fangzhou
- Guo, Weisheng
- Xu, Lijun
- Chen, Meiwan
- Fan, Yubo
- Zhang, Liwei
- Liang, Xing‐Jie
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