Anchoring Supramolecular Polymers to Human Red Blood Cells by Combining Dynamic Covalent and Non‐Covalent Chemistries
Abstract: Understanding cell/material interactions is essential to design functional cell‐responsive materials. While the scientific literature abounds with formulations of biomimetic materials, only a fraction of them focused on mechanisms of the molecular interactions between cells and material. To provide new knowledge on the strategies for materials/cell recognition and binding, supramolecular benzene‐1,3,5‐tricarboxamide copolymers bearing benzoxaborole moieties are anchored on the surface of human erythrocytes via benzoxaborole/sialic‐acid binding. This interaction based on both dynamic covalent and non‐covalent chemistries is visualized in real time by means of total internal reflection fluorescence microscopy. Exploiting this imaging method, we observe that the functional copolymers specifically interact with the cell surface. An optimal fiber affinity towards the cells as a function of benzoxaborole concentration demonstrates the crucial role of multivalency in these cell/material interactions.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Anchoring Supramolecular Polymers to Human Red Blood Cells by Combining Dynamic Covalent and Non‐Covalent Chemistries ; volume:59 ; number:39 ; year:2020 ; pages:17229-17233 ; extent:5
Angewandte Chemie / International edition. International edition ; 59, Heft 39 (2020), 17229-17233 (gesamt 5)
- Creator
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Morgese, Giulia
de Waal, Bas F. M.
Varela‐Aramburu, Silvia
Palmans, Anja R. A.
Albertazzi, Lorenzo
Meijer, E. W.
- DOI
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10.1002/anie.202006381
- URN
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urn:nbn:de:101:1-2022061907012189572413
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:22 AM CEST
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Associated
- Morgese, Giulia
- de Waal, Bas F. M.
- Varela‐Aramburu, Silvia
- Palmans, Anja R. A.
- Albertazzi, Lorenzo
- Meijer, E. W.
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Microscopic strain mapping in polymers equipped with non-covalent mechanochromic motifs
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Covalent-supramolecular hybrid polymers as muscle-inspired anisotropic actuators