Adeno-Associated Viral Vectors for Gene Transfer and Gene Therapy
Abstract: Adeno-associated virus (AAV) is a defective, non-pathogenic human parvovirus that depends for growth on coinfection with a helper adenovirus or herpes virus. Recombinant adeno-associated viruses (rAAVs) have attracted considerable interest as vectors for gene therapy. In contrast to other gene delivery systems, rAAVs lack all viral genes and show long-term gene expression in vivo without immune response or toxicity. Over the past few years, many applications of rAAVs as therapeutic agents have demonstrated the utility of this vector system for long-lasting genetic modification and gene therapy in preclinical models of human disease. New production methods have increased rAAV vector titers and eliminated contamination by adenovirus. In addition, vectors for regulatable gene expression and vectors retargeted to different cells have been engineered. These advancements are expected to accelerate and facilitate further animal model studies, providing validation for use of rAAVs in human clinical trials.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Adeno-Associated Viral Vectors for Gene Transfer and Gene Therapy ; volume:380 ; number:6 ; year:1999 ; pages:613-622
Biological chemistry ; 380, Heft 6 (1999), 613-622
- Urheber
-
Büeler, H.
- DOI
-
10.1515/BC.1999.078
- URN
-
urn:nbn:de:101:1-2406111612201.381779489482
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
14.08.2025, 10:49 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Büeler, H.
Ähnliche Objekte (12)
Adeno-Associated Virus (AAV) vectors in gene therapy
Designer Gene Delivery Vectors: Molecular Engineering and Evolution of Adeno-Associated Viral Vectors for Enhanced Gene Transfer
Generation of a shut-off system for Adeno-associated viral gene transfer vectors
Generation of a shut-off system for Adeno-associated viral gene transfer vectors
Hepatotoxicity in Adeno-Associated Viral Vector Gene Therapy
Development of viral tools for CNS gene transfer : adeno-associated viral vectors in gene therapy of Parkinson's disease
Evaluation of humanized mouse models and adeno-associated viral vectors for HIV gene therapy
Advances in designing Adeno-associated viral vectors for development of anti-HBV gene therapeutics
Improving safety and establishing episomal maintenance of Adeno-associated viral vectors
Synthetic biology: emerging concepts to design and advance adeno‐associated viral vectors for gene therapy
Synthetic Biology: Emerging Concepts to Design and Advance Adeno‐Associated Viral Vectors for Gene Therapy
Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain
Adeno-Associated Virus (AAV) vectors in gene therapy
Designer Gene Delivery Vectors: Molecular Engineering and Evolution of Adeno-Associated Viral Vectors for Enhanced Gene Transfer
Generation of a shut-off system for Adeno-associated viral gene transfer vectors
Generation of a shut-off system for Adeno-associated viral gene transfer vectors
Hepatotoxicity in Adeno-Associated Viral Vector Gene Therapy
Development of viral tools for CNS gene transfer : adeno-associated viral vectors in gene therapy of Parkinson's disease
Evaluation of humanized mouse models and adeno-associated viral vectors for HIV gene therapy
Advances in designing Adeno-associated viral vectors for development of anti-HBV gene therapeutics
Improving safety and establishing episomal maintenance of Adeno-associated viral vectors
Synthetic biology: emerging concepts to design and advance adeno‐associated viral vectors for gene therapy
Synthetic Biology: Emerging Concepts to Design and Advance Adeno‐Associated Viral Vectors for Gene Therapy
Adeno-associated viral vectors for functional intravenous gene transfer throughout the non-human primate brain
Adeno-Associated Virus (AAV) vectors in gene therapy
Designer Gene Delivery Vectors: Molecular Engineering and Evolution of Adeno-Associated Viral Vectors for Enhanced Gene Transfer
Generation of a shut-off system for Adeno-associated viral gene transfer vectors
Generation of a shut-off system for Adeno-associated viral gene transfer vectors
Hepatotoxicity in Adeno-Associated Viral Vector Gene Therapy
Development of viral tools for CNS gene transfer : adeno-associated viral vectors in gene therapy of Parkinson's disease
Evaluation of humanized mouse models and adeno-associated viral vectors for HIV gene therapy
Advances in designing Adeno-associated viral vectors for development of anti-HBV gene therapeutics
Improving safety and establishing episomal maintenance of Adeno-associated viral vectors
Synthetic biology: emerging concepts to design and advance adeno‐associated viral vectors for gene therapy
Synthetic Biology: Emerging Concepts to Design and Advance Adeno‐Associated Viral Vectors for Gene Therapy