Dosing and treatment duration of suppressive antimicrobial therapy in orthopedic implant infections: a cohort study
Abstract Introduction n = 82) was not associated with failure in univariate (hazard ratio (HR) 1.23, 95 % confidence interval (CI) 0.53–2.83) and multivariate analyses (HR 1.24, 95 % CI 0.54–2.90). In 25 patients (23 %), SAT was stopped after a median treatment duration of 26 months. In this group, one patient (4 %) developed a relapse. Conclusions: In this study, low-dosage SAT was as effective as standard dosage SAT. Moreover, stopping SAT after 2 to 3 years may be justified in patients with a good clinical course. These findings warrant further research on optimal dosing and duration of SAT and on the durability of in vivo biofilms.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Dosing and treatment duration of suppressive antimicrobial therapy in orthopedic implant infections: a cohort study ; volume:9 ; number:3 ; year:2024 ; pages:149-159 ; extent:11
Journal of bone and joint infection ; 9, Heft 3 (2024), 149-159 (gesamt 11)
- Urheber
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Hanssen, Jaap L. J.
van der Wal, Robert J. P.
van der Linden, Henrica M. J.
van Prehn, Joffrey
Scheper, Henk
de Boer, Mark G. J.
- DOI
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10.5194/jbji-9-149-2024
- URN
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urn:nbn:de:101:1-2406060416132.938802514265
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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14.08.2025, 10:50 MESZ
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Beteiligte
- Hanssen, Jaap L. J.
- van der Wal, Robert J. P.
- van der Linden, Henrica M. J.
- van Prehn, Joffrey
- Scheper, Henk
- de Boer, Mark G. J.
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