Dosing and treatment duration of suppressive antimicrobial therapy in orthopedic implant infections: a cohort study

Abstract Introduction n = 82) was not associated with failure in univariate (hazard ratio (HR) 1.23, 95 % confidence interval (CI) 0.53–2.83) and multivariate analyses (HR 1.24, 95 % CI 0.54–2.90). In 25 patients (23 %), SAT was stopped after a median treatment duration of 26 months. In this group, one patient (4 %) developed a relapse. Conclusions: In this study, low-dosage SAT was as effective as standard dosage SAT. Moreover, stopping SAT after 2 to 3 years may be justified in patients with a good clinical course. These findings warrant further research on optimal dosing and duration of SAT and on the durability of in vivo biofilms.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Dosing and treatment duration of suppressive antimicrobial therapy in orthopedic implant infections: a cohort study ; volume:9 ; number:3 ; year:2024 ; pages:149-159 ; extent:11 ; Journal of bone and joint infection ; 9, Heft 3 (2024), 149-159 (gesamt 11)

Contributors, Places and Time

• Creator: Hanssen, Jaap L. J. ; van der Wal, Robert J. P. ; van der Linden, Henrica M. J. ; van Prehn, Joffrey ; Scheper, Henk ; de Boer, Mark G. J.

Further information

• DOI: 10.5194/jbji-9-149-2024
• URN: urn:nbn:de:101:1-2406060416132.938802514265
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:50 AM CEST