A simple approach for molecular controlled release based on atomic layer deposition hybridized organic-inorganic layers
Abstract: On-demand release of bioactive substances with high spatial and temporal control offers ground-breaking possibilities in the field of life sciences. However, available strategies for developing such release systems lack the possibility of combining efficient control over release with adequate storage capability in a reasonably compact system. In this study we present a new approach to target this deficiency by the introduction of a hybrid material. This organic-inorganic material was fabricated by atomic layer deposition of ZnO into thin films of polyethylene glycol, forming the carrier matrix for the substance to be released. Sub-surface growth mechanisms during this process converted the liquid polymer into a solid, yet water-soluble, phase. This layer permits extended storage for various substances within a single film of only a few micrometers in thickness, and hence demands minimal space and complexity. Improved control over release of the model substance Fluorescein was achieved by coating the hybrid material with a conducting polymer film. Single dosage and repetitive dispensing from this system was demonstrated. Release was controlled by applying a bias potential of ±0.5 V to the polymer film enabling or respectively suppressing the expulsion of the model drug. In vitro tests showed excellent biocompatibility of the presented system
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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Scientific Reports. 6 (2016), 19574, DOI 10.1038/srep19574, issn: 2045-2322
IN COPYRIGHT http://rightsstatements.org/page/InC/1.0 rs
- Classification
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Physik
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
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Universität
- (when)
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2016
- Contributor
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Freiburg Institute for Advanced Studies
Albert-Ludwigs-Universität Freiburg
Professur für Nanotechnologie
Technische Fakultät
- DOI
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10.1038/srep19574
- URN
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urn:nbn:de:bsz:25-freidok-121417
- Rights
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Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 10:44 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Böhler, Christian
- Güder, Firat
- Küçükbayrak, Umut Memet
- Zacharias, Margit
- Asplund, Maria
- Freiburg Institute for Advanced Studies
- Albert-Ludwigs-Universität Freiburg
- Professur für Nanotechnologie
- Technische Fakultät
- Universität
Time of origin
- 2016
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