Hdac1 and Hdac2 are essential for physiological maturation of a Cx3cr1 expressing subset of T-lymphocytes

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Abstract: Objective
Histone acetylation is an important mechanism in the regulation of gene expression and plays a crucial role in both cellular development and cellular response to external or internal stimuli. One key aspect of this form of regulation is that acetylation marks can be added and removed from sites of regulation very quickly through the activity of histone acetyltransferases (HATs) and histone deacetylases (HDACs). The activity of both HATs and HDACs has been shown to be important for both physiological hematopoiesis as well as during development of hematological neoplasia, such as lymphomas. In the present study we analyzed the effect of knockout of the two HDACs, Hdac1 and Hdac2 in cells expressing the fractalkine receptor (Cx3cr1) on lymphocyte development.

Results
We report data showing a maturation defect in mice harboring a Cx3cr1 dependent knockout of Hdac1 and 2. Furthermore, we report that these mice develop a T-cell neoplasia at about 4–5 months of age, suggesting that a Cx3cr1 expressing subpopulation of immature T-cells gives rise to T-cell lymphomas in the combined absence of Hdac1 and Hdac2

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Notes: BMC research notes. - 14, 1 (2021) , 135, ISSN: 1756-0500

Event: Veröffentlichung

(where): Freiburg

(who): Universität

(when): 2021

Creator: Datta, Moumita
Staszewski, Ori

DOI: 10.1186/s13104-021-05551-6

URN: urn:nbn:de:bsz:25-freidok-2184975

Rights: Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 10:56 AM CEST

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Associated

Time of origin

2021

Other Objects (12)

Hdac1 and Hdac2 are essential for physiological maturation of a Cx3cr1 expressing subset of T-lymphocytes

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ASME-PEARL-Subset

ASME-PEARL-Subset

Hdac1 and Hdac2 are essential for physiological maturation of a Cx3cr1 expressing subset of T-lymphocytes

Hdac1 and Hdac2 are essential for physiological maturation of a Cx3cr1 expressing subset of T-lymphocytes

An overlooked subset of Cx3cr1 wt/wt microglia in the Cx3cr1 CreER-Eyfp/wt mouse has a repopulation advantage over Cx3cr1 CreER-Eyfp/wt microglia following microglial depletion

An overlooked subset of Cx3cr1 wt/wt microglia in the Cx3cr1 CreER-Eyfp/wt mouse has a repopulation advantage over Cx3cr1 CreER-Eyfp/wt microglia following microglial depletion

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Reduced Fas ligand-expressing splenic CD5+B lymphocytes in severe collagen-induced arthritis

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The cellular microenvironment regulates CX3CR1 expression on CD8 + T cells and the maintenance of CX3CR1 + CD8 + T cells

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ASME-PEARL-Subset

ASME-PEARL-Subset

Hdac1 and Hdac2 are essential for physiological maturation of a Cx3cr1 expressing subset of T-lymphocytes

Hdac1 and Hdac2 are essential for physiological maturation of a Cx3cr1 expressing subset of T-lymphocytes

An overlooked subset of Cx3cr1 wt/wt microglia in the Cx3cr1 CreER-Eyfp/wt mouse has a repopulation advantage over Cx3cr1 CreER-Eyfp/wt microglia following microglial depletion

An overlooked subset of Cx3cr1 wt/wt microglia in the Cx3cr1 CreER-Eyfp/wt mouse has a repopulation advantage over Cx3cr1 CreER-Eyfp/wt microglia following microglial depletion

Maturation, acidification and fusion of cytotoxic granules in primary CD8+ T lymphocytes

Maturation, acidification and fusion of cytotoxic granules in primary CD8+ T lymphocytes

Reduced Fas ligand-expressing splenic CD5+B lymphocytes in severe collagen-induced arthritis

Reduced Fas ligand-expressing splenic CD5+B lymphocytes in severe collagen-induced arthritis

The cellular microenvironment regulates CX3CR1 expression on CD8 + T cells and the maintenance of CX3CR1 + CD8 + T cells

The cellular microenvironment regulates CX3CR1 expression on CD8 + T cells and the maintenance of CX3CR1 + CD8 + T cells

TIGIT expressing CD4+T cells represent a tumor-supportive T cell subset in chronic lymphocytic leukemia

TIGIT expressing CD4+T cells represent a tumor-supportive T cell subset in chronic lymphocytic leukemia

Defining a TCF1-expressing progenitor allogeneic CD8+ T cell subset in acute graft-versus-host disease

Defining a TCF1-expressing progenitor allogeneic CD8+ T cell subset in acute graft-versus-host disease

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Paracoccidioides brasiliensis infection promotes thymic disarrangement and premature egress of mature lymphocytes expressing prohibitive TCRs

ASME-PEARL-Subset

ASME-PEARL-Subset

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