Small vessel occlusion and syphilis in patients with first-ever ischemic stroke

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Abstract: Background: Syphilis is an endemic disease, particularly in low- and middle-income countries, with vascular involvement in large vessels (aortitis), but no clear relationship with stroke patients, except for those who presented with meningovascular neurosyphilis. Objective: To investigate the relationship between a positive history of syphilis determined by serological testing and ischemic stroke etiology, particularly small vessel disease (SVD). Methods: In total, 269 first-ever ischemic stroke patients admitted to the stroke unit were tested for syphilis. Patients with neurosyphilis were excluded. All patients were classified according to the ASCOD phenotyping as SVD — when SVD was the potential causal mechanism (S1) — or non-SVD — when SVD was uncertain (S2), unlike (S3), or not detected (S0). Results: Syphilis was positive in 32 (12%) patients. When comparing patients with positive and negative serology, the only significant difference was SVD as the causal mechanism (S1) in patients with positive results: 9 (28%) vs. 22 (9%), p<0.01. Conclusion: The current study showed that the frequency of positive syphilis serological test was higher in patients with first-ever ischemic stroke and SVD as the potential causal mechanism. This finding could be related to the endothelial dysfunction occurring in syphilis.

Alternative title
Oclusão de pequenos vasos e sífilis em pacientes com o primeiro acidente vascular cerebral isquêmico
Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch

Bibliographic citation
Small vessel occlusion and syphilis in patients with first-ever ischemic stroke ; volume:79 ; number:02 ; year:2021 ; pages:103-106
Arquivos de neuro-psiquiatria ; 79, Heft 02 (2021), 103-106

Contributor
Ferreira, Matheus Gomes
Scavasine, Valeria Cristina
Breda, Giovanni Luís
Almeida, Bernardo Montesanti Machado de
Zétola, Viviane de Hiroki Flumignan
Lange, Marcos Christiano

DOI
10.1590/0004-282X-anp-2020-0178
URN
urn:nbn:de:101:1-2023081711112841353483
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
14.08.2025, 10:58 AM CEST

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Associated

  • Ferreira, Matheus Gomes
  • Scavasine, Valeria Cristina
  • Breda, Giovanni Luís
  • Almeida, Bernardo Montesanti Machado de
  • Zétola, Viviane de Hiroki Flumignan
  • Lange, Marcos Christiano

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