Covalently Cross‐Linked Pig Gastric Mucin Hydrogels Prepared by Radical‐Based Chain‐Growth and Thiol‐ene Mechanisms
Abstract: Mucin, a high molecular mass hydrophilic glycoprotein, is the main component of mucus that coats every wet epithelium in animals. It is thus intrinsically biocompatible, and with its protein backbone and the o‐glycosidic bound oligosaccharides, it contains a plethora of functional groups which can be used for further chemical modifications. Here, chain‐growth and step‐growth (thiol‐ene) free‐radical cross‐linked hydrogels prepared from commercially available pig gastric mucin (PGM) are introduced and compared as cost‐efficient and easily accessible alternative to the more broadly applied bovine submaxillary gland mucin. For this, PGM is functionalized with photoreactive acrylate groups or allyl ether moieties, respectively. Whereas homopolymerization of acrylate‐functionalized polymers is performed, for thiol‐ene cross‐linking, the allyl‐ether‐functionalized PGM is cross‐linked with thiol‐functionalized hyaluronic acid. Morphology, mechanical properties, and cell compatibility of both kinds of PGM hydrogels are characterized and compared. Furthermore, the biocompatibility of these hydrogels can be evaluated in cell culture experiments.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Covalently Cross‐Linked Pig Gastric Mucin Hydrogels Prepared by Radical‐Based Chain‐Growth and Thiol‐ene Mechanisms ; day:27 ; month:01 ; year:2022 ; extent:9
Macromolecular bioscience ; (27.01.2022) (gesamt 9)
- Urheber
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Brand, Jessica S.
Forster, Leonard
Böck, Thomas
Stahlhut, Philipp
Teßmar, Jörg
Groll, Jürgen
Albrecht, Krystyna
- DOI
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10.1002/mabi.202100274
- URN
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urn:nbn:de:101:1-2022012814012926659995
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:40 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Brand, Jessica S.
- Forster, Leonard
- Böck, Thomas
- Stahlhut, Philipp
- Teßmar, Jörg
- Groll, Jürgen
- Albrecht, Krystyna
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