Chemical and Photophysical Triggers for the Reduction of Pt (IV) Prodrugs for Anticancer Therapy
Abstract: Platinum (II) complexes are used in approximately 50% of chemotherapeutic treatments worldwide. Despite their undoubtful clinical success, these compounds are associated with severe side effects and poor tumor selectivity. To overcome these drawbacks, the development of platinum (IV) molecular prodrugs and nanoparticle formulations that remain stable and therapeutically inactive in a biological environment, but could be quickly reduced into the therapeutically active analogs through a specific trigger have been thought. Within this article, the mechanisms for chemical and photophysical triggers for the activation of platinum (IV) prodrugs have been critically reviewed.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Chemical and Photophysical Triggers for the Reduction of Pt (IV) Prodrugs for Anticancer Therapy ; day:27 ; month:07 ; year:2023 ; extent:12
ChemNanoMat ; (27.07.2023) (gesamt 12)
- Creator
- DOI
-
10.1002/cnma.202300295
- URN
-
urn:nbn:de:101:1-2023072715241177327575
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
14.08.2025, 10:50 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
Other Objects (12)
Aminoferrocene‐Based Anticancer Prodrugs Labelled with Cyanine Dyes for in vivo Imaging
Aminoferrocene‐Based Anticancer Prodrugs Labelled with Cyanine Dyes for in vivo Imaging
Bioreductive prodrugs for the targeting of epigenetic enzymes
Dual‐Targeted Nanoreactors and Prodrugs: Hydrogen Peroxide Triggers Oxidative Damage and Prodrug Activation for Synergistic Elimination of Cancer Cells
Binuclear Biphenyl Organogold (III) Complexes: Synthesis, Photophysical and Theoretical Investigation, and Anticancer Activity
Re-design and evaluation of diclofenac-based carborane-substituted prodrugs and their anti-cancer potential
Mutual Prodrugs of 5‐Fluorouracil: From a Classic Chemotherapeutic Agent to Novel Potential Anticancer Drugs
Injectable Autocatalytic Hydrogel Triggers Pyroptosis to Stimulate Anticancer Immune Response for Preventing Postoperative Tumor Recurrence
Aminoferrocen-basierte, krebsspezifische Prodrugs
Synthese von Entacapon-Prodrugs
"Prodrugs" glycerolipidiques comme systeme pharmaceutique
Carbamates as potential prodrugs and a new warhead for HDAC inhibition
Aminoferrocene‐Based Anticancer Prodrugs Labelled with Cyanine Dyes for in vivo Imaging
Aminoferrocene‐Based Anticancer Prodrugs Labelled with Cyanine Dyes for in vivo Imaging
Bioreductive prodrugs for the targeting of epigenetic enzymes
Dual‐Targeted Nanoreactors and Prodrugs: Hydrogen Peroxide Triggers Oxidative Damage and Prodrug Activation for Synergistic Elimination of Cancer Cells
Binuclear Biphenyl Organogold (III) Complexes: Synthesis, Photophysical and Theoretical Investigation, and Anticancer Activity
Re-design and evaluation of diclofenac-based carborane-substituted prodrugs and their anti-cancer potential
Mutual Prodrugs of 5‐Fluorouracil: From a Classic Chemotherapeutic Agent to Novel Potential Anticancer Drugs
Injectable Autocatalytic Hydrogel Triggers Pyroptosis to Stimulate Anticancer Immune Response for Preventing Postoperative Tumor Recurrence
Aminoferrocen-basierte, krebsspezifische Prodrugs
Synthese von Entacapon-Prodrugs
"Prodrugs" glycerolipidiques comme systeme pharmaceutique
Carbamates as potential prodrugs and a new warhead for HDAC inhibition
Aminoferrocene‐Based Anticancer Prodrugs Labelled with Cyanine Dyes for in vivo Imaging
Aminoferrocene‐Based Anticancer Prodrugs Labelled with Cyanine Dyes for in vivo Imaging
Bioreductive prodrugs for the targeting of epigenetic enzymes
Dual‐Targeted Nanoreactors and Prodrugs: Hydrogen Peroxide Triggers Oxidative Damage and Prodrug Activation for Synergistic Elimination of Cancer Cells
Binuclear Biphenyl Organogold (III) Complexes: Synthesis, Photophysical and Theoretical Investigation, and Anticancer Activity
Re-design and evaluation of diclofenac-based carborane-substituted prodrugs and their anti-cancer potential
Mutual Prodrugs of 5‐Fluorouracil: From a Classic Chemotherapeutic Agent to Novel Potential Anticancer Drugs
Injectable Autocatalytic Hydrogel Triggers Pyroptosis to Stimulate Anticancer Immune Response for Preventing Postoperative Tumor Recurrence
Aminoferrocen-basierte, krebsspezifische Prodrugs
Synthese von Entacapon-Prodrugs
"Prodrugs" glycerolipidiques comme systeme pharmaceutique