Structure of the human 20S U5 snRNP
Abstract: The 20S U5 small nuclear ribonucleoprotein particle (snRNP) is a 17-subunit RNA–protein complex and a precursor of the U4/U6.U5 tri-snRNP, the major building block of the precatalytic spliceosome. CD2BP2 is a hallmark protein of the 20S U5 snRNP, absent from the mature tri-snRNP. Here we report a high-resolution cryogenic electron microscopy structure of the 20S U5 snRNP, shedding light on the mutually exclusive interfaces utilized during tri-snRNP assembly and the role of the CD2BP2 in facilitating this process
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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Nature structural & molecular biology. - 31, 5 (2024) , 752-756, ISSN: 1545-9985
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
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Universität
- (wann)
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2024
- Urheber
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Schneider, Sarah
Brandina, Irina
Peter, Daniel
Lagad, Sonal
Fraudeau, Angelique
Portell-Montserrat, Júlia
Tholen, Jonas
Zhao, Jiangfeng
Galej, Wojciech P.
- DOI
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10.1038/s41594-024-01250-5
- URN
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urn:nbn:de:bsz:25-freidok-2569857
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:25 MESZ
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Beteiligte
- Schneider, Sarah
- Brandina, Irina
- Peter, Daniel
- Lagad, Sonal
- Fraudeau, Angelique
- Portell-Montserrat, Júlia
- Tholen, Jonas
- Zhao, Jiangfeng
- Galej, Wojciech P.
- Universität
Entstanden
- 2024
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