Structure of the human 20S U5 snRNP
Abstract: The 20S U5 small nuclear ribonucleoprotein particle (snRNP) is a 17-subunit RNA–protein complex and a precursor of the U4/U6.U5 tri-snRNP, the major building block of the precatalytic spliceosome. CD2BP2 is a hallmark protein of the 20S U5 snRNP, absent from the mature tri-snRNP. Here we report a high-resolution cryogenic electron microscopy structure of the 20S U5 snRNP, shedding light on the mutually exclusive interfaces utilized during tri-snRNP assembly and the role of the CD2BP2 in facilitating this process
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Notes
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Nature structural & molecular biology. - 31, 5 (2024) , 752-756, ISSN: 1545-9985
- Event
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Veröffentlichung
- (where)
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Freiburg
- (who)
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Universität
- (when)
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2024
- Creator
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Schneider, Sarah
Brandina, Irina
Peter, Daniel
Lagad, Sonal
Fraudeau, Angelique
Portell-Montserrat, Júlia
Tholen, Jonas
Zhao, Jiangfeng
Galej, Wojciech P.
- DOI
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10.1038/s41594-024-01250-5
- URN
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urn:nbn:de:bsz:25-freidok-2569857
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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15.08.2025, 7:25 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Schneider, Sarah
- Brandina, Irina
- Peter, Daniel
- Lagad, Sonal
- Fraudeau, Angelique
- Portell-Montserrat, Júlia
- Tholen, Jonas
- Zhao, Jiangfeng
- Galej, Wojciech P.
- Universität
Time of origin
- 2024
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Structure of the human 20S U5 snRNP
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Beyond splicing: roles of U5 snRNP in the cellular stress response, growth and proteostasis
Funktionsanalyse der humanen U5 snRNA
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Investigation of the structurally related U4 snRNP, U4atac snRNP and box C/D s(no)RNPs
Co-transcriptional recruitment of the U1 snRNP
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Co-transcriptional recruitment of the U1 snRNP
U1 snRNP Biogenesis Defects in Neurodegenerative Diseases