Enzymatic Fluoromethylation as a Tool for ATP‐Independent Ligation

Abstract: S‐adenosylmethionine‐dependent methyltransferases are involved in countless biological processes, including signal transduction, epigenetics, natural product biosynthesis, and detoxification. Only a handful of carboxylate methyltransferases have evolved to participate in amide bond formation. In this report we show that enzyme‐catalyzed F‐methylation of carboxylate substrates produces F‐methyl esters that readily react with N‐ or S‐nucleophiles under physiological conditions. We demonstrate the applicability of this approach to the synthesis of small amides, hydroxamates, and thioesters, as well as to site‐specific protein modification and native chemical ligation.

Standort
Deutsche Nationalbibliothek Frankfurt am Main
Umfang
Online-Ressource
Sprache
Englisch

Erschienen in
Enzymatic Fluoromethylation as a Tool for ATP‐Independent Ligation ; day:29 ; month:11 ; year:2023 ; extent:9
Angewandte Chemie / International edition. International edition ; (29.11.2023) (gesamt 9)

Urheber
Peng, Jiaming
Hughes, Gregory R.
Müller, Manuel M.
Seebeck, Florian Peter

DOI
10.1002/anie.202312104
URN
urn:nbn:de:101:1-2023113014114287860151
Rechteinformation
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Letzte Aktualisierung
15.08.2025, 07:25 MESZ

Datenpartner

Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.

Beteiligte

Ähnliche Objekte (12)