Enzymatic Fluoromethylation as a Tool for ATP‐Independent Ligation
Abstract: S‐adenosylmethionine‐dependent methyltransferases are involved in countless biological processes, including signal transduction, epigenetics, natural product biosynthesis, and detoxification. Only a handful of carboxylate methyltransferases have evolved to participate in amide bond formation. In this report we show that enzyme‐catalyzed F‐methylation of carboxylate substrates produces F‐methyl esters that readily react with N‐ or S‐nucleophiles under physiological conditions. We demonstrate the applicability of this approach to the synthesis of small amides, hydroxamates, and thioesters, as well as to site‐specific protein modification and native chemical ligation.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Enzymatic Fluoromethylation as a Tool for ATP‐Independent Ligation ; day:29 ; month:11 ; year:2023 ; extent:9
Angewandte Chemie / International edition. International edition ; (29.11.2023) (gesamt 9)
- Urheber
- DOI
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10.1002/anie.202312104
- URN
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urn:nbn:de:101:1-2023113014114287860151
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:25 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Peng, Jiaming
- Hughes, Gregory R.
- Müller, Manuel M.
- Seebeck, Florian Peter