Nonribosomal Peptides Produced by Minimal and Engineered Synthetases with Terminal Reductase Domains

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Abstract: Nonribosomal peptide synthetases (NRPSs) use terminal reductase domains for 2‐electron reduction of the enzyme‐bound thioester releasing the generated peptides as C‐terminal aldehydes. Herein, we reveal the biosynthesis of a pyrazine that originates from an aldehyde‐generating minimal NRPS termed ATRed in entomopathogenic Xenorhabdus indica. Reductase domains were also investigated in terms of NRPS engineering and, although no general applicable approach was deduced, we show that they can indeed be used for the production of similar natural and unnatural pyrazinones.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Nonribosomal Peptides Produced by Minimal and Engineered Synthetases with Terminal Reductase Domains ; volume:21 ; number:19 ; year:2020 ; pages:2750-2754 ; extent:5
ChemBioChem ; 21, Heft 19 (2020), 2750-2754 (gesamt 5)

Creator: Tietze, Andreas
Shi, Yan‐Ni
Kronenwerth, Max
Bode, Helge Björn

DOI: 10.1002/cbic.202000176

URN: urn:nbn:de:101:1-2022061907195963014341

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:28 AM CEST

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