Hyalocytes in proliferative vitreo-retinal diseases

Abstract: Introduction

Hyalocytes are sentinel macrophages residing within the posterior vitreous cortex anterior to the retinal inner limiting membrane (ILM). Following anomalous PVD and vitreoschisis, hyalocytes contribute to paucicellular (vitreo-macular traction syndrome, macular holes) and hypercellular (macular pucker, proliferative vitreo-retinopathy, proliferative diabetic vitreo-retinopathy) diseases.
Areas covered

Studies of human tissues employing dark-field, phase, and electron microscopies; immunohistochemistry; and in vivo imaging of human hyalocytes.
Expert opinion

Hyalocytes are important in early pathophysiology, stimulating cell migration and proliferation, as well as subsequent membrane contraction and vitreo-retinal traction. Targeting hyalocytes early could mitigate advanced disease. Ultimately, eliminating the role of vitreous and hyalocytes may prevent proliferative vitreo-retinal diseases entirely

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch
• Notes: Expert review of ophthalmology. - 17, 4 (2022) , 263-280, ISSN: 1746-9902

Contributors, Places and Time

• Event: Veröffentlichung
• (where): Freiburg
• (who): Universität
• (when): 2022
• Creator: Jones, Charlotte H. ; Gui, Wei ; Schumann, Ricarda G. ; Boneva, Stefaniya ; Lange, Clemens ; Overdam, Koen A. van ; Chui, Toco Y. P. ; Rosen, Richard B. ; Engelbert, Michael ; Sebag, Jerry

Further information

• DOI: 10.1080/17469899.2022.2100764
• URN: urn:nbn:de:bsz:25-freidok-2296830
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 25.03.2025, 1:43 PM CET