Sema3f protects against subretinal neovascularization in vivo

Abstract: Pathological neovascularization of the outer retina is the hallmark of neovascular age-related macular degeneration (nAMD). Building on our previous observations that semaphorin 3F (Sema3f) is expressed in the outer retina and demonstrates anti-angiogenic potential, we have investigated whether Sema3f can be used to protect against subretinal neovascularization in two mouse models. Both in the very low-density lipid-receptor knockout (Vldlr−/−) model of spontaneous subretinal neovascularization as well as in the mouse model of laser-induced choroidal neovascularization (CNV), we found protective effects of Sema3f against the formation of pathologic neovascularization. In the Vldlr−/− model, AAV-induced overexpression of Sema3f reduced the size of pathologic neovascularization by 56%. In the laser-induced CNV model, intravitreally injected Sema3f reduced pathologic neovascularization by 30%. Combined, these results provide the first evidence from two distinct in vivo models for a use of Sema3f in protecting the outer retina against subretinal neovascularization

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch
• Anmerkungen: EBioMedicine. - 18 (2017) , 281-287, ISSN: 2352-3964

Beteiligte, Orts- und Zeitangaben

• Ereignis: Veröffentlichung
• (wo): Freiburg
• (wer): Universität
• (wann): 2019
• Urheber: Sun, Ye ; Liegl, Raffael ; Gong, Yan ; Bühler, Anima Désirée ; Cakir, Bertan ; Meng, Steven S. ; Burnim, Samuel B. ; Liu, Chi-Hsiu ; Reuer, Tristan ; Zhang, Pei Pei ; Walz, Johanna M. ; Ludwig, Franziska ; Lange, Clemens ; Agostini, Hansjürgen ; Böhringer, Daniel ; Schlunck, Günther ; Smith, Lois E. H. ; Stahl, Andreas

Weitere Informationen

• DOI: 10.1016/j.ebiom.2017.03.026
• URN: urn:nbn:de:bsz:25-freidok-1408955
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 11:00 MESZ