High-complexity regions in mammalian genomes are enriched for developmental genes
Abstract: Unique sequence regions are associated with genetic function in vertebrate genomes. However, measuring uniqueness, or absence of long repeats, along a genome is conceptually and computationally difficult. Here we use a variant of the Lempel--Ziv complexity, the match complexity, $C_m$, and augment it by deriving its null distribution for random sequences. We then apply $C_m$ to the human and mouse genomes to investigate the relationship between sequence complexity and function
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Anmerkungen
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Bioinformatics. - 35, 11 (2019) , 1813-1819, ISSN: 1460-2059
- Ereignis
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Veröffentlichung
- (wo)
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Freiburg
- (wer)
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Universität
- (wann)
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2021
- Urheber
- DOI
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10.1093/bioinformatics/bty922
- URN
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urn:nbn:de:bsz:25-freidok-2217209
- Rechteinformation
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Kein Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:37 MESZ
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Beteiligte
- Pirogov, Anton
- Pfaffelhuber, Peter
- Börsch-Haubold, Angelika
- Haubold, Bernhard
- Universität
Entstanden
- 2021
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