Longitudinal clinical phenotyping of post COVID condition in Mexican adults recovering from severe COVID-19: a prospective cohort study

Abstract: Introduction: Few studies have evaluated the presence of Post COVID-19 conditions (PCC) in people from Latin America, a region that has been heavily afflicted by the COVID-19 pandemic. In this study, we describe the frequency, co-occurrence, predictors, and duration of 23 symptoms in a cohort of Mexican patients with PCC.

Methods: We prospectively enrolled and followed adult patients hospitalized for severe COVID-19 at a tertiary care centre in Mexico City. The incidence of PCC symptoms was determined using questionnaires. Unsupervised clustering of PCC symptom co-occurrence and Kaplan–Meier analyses of symptom persistence were performed. The effect of baseline clinical characteristics was evaluated using Cox regression models and reported with hazard ratios (HR).

Results: We found that amongst 192 patients with PCC, respiratory problems were the most prevalent and commonly co-occurred with functional activity impairment. 56% had ≥5 persistent symptoms. Symptom persistence probability at 360 days 0.78. Prior SARS-CoV-2 vaccination and infection during the Delta variant wave were associated with a shorter duration of PCC. Male sex was associated with a shorter duration of functional activity impairment and respiratory symptoms. Hypertension and diabetes were associated with a longer duration of functional impairment. Previous vaccination accelerated PCC recovery.

Discussion: In our cohort, PCC symptoms were frequent (particularly respiratory and neurocognitive ones) and persistent. Importantly, prior SARS-CoV-2 vaccination resulted in a shorter duration of PCC

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch
• Notes: Frontiers in medicine. - 10 (2023) , 1236702, ISSN: 2296-858X

Contributors, Places and Time

• Event: Veröffentlichung
• (where): Freiburg
• (who): Universität
• (when): 2023
• Creator: Núñez, Isaac ; Gillard, Joshua ; Fragoso-Saavedra, Sergio ; Feyaerts, Dorien ; Islas-Weinstein, León ; Gallegos-Guzmán, Angel A. ; Valente-García, Uriel ; Meyerowitz, Justin ; Kelly, J. Daniel ; Chen, Han ; Ganio, Edward ; Benkendorff, Alexander ; Flores-Gouyonnet, Jaime ; Dammann-Beltrán, Pedro ; Heredia-González, José Francisco ; Rangel-Gutiérrez, Gabriela A. ; Blish, Catherine A. ; Nadeau, Kari C. ; Nolan, Garry ; Crispín, Jose C. ; McIlwain, David R. ; Gaudillière, Brice ; Valdés-Ferrer, Sergio I.

Further information

• DOI: 10.3389/fmed.2023.1236702
• URN: urn:nbn:de:bsz:25-freidok-2396902
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 25.03.2025, 1:41 PM CET