Decarboxylative Iodination of Coumarin‐3‐carboxylic Acids: A Facile Access to 3‐Iodocoumarins

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Abstract: A straightforward protocol for the direct conversion of readily available coumarin‐3‐carboxylic acids to the corresponding 3‐iodocoumarins is described herein. Heating acetonitrile solution of coumarin‐3‐carboxylic acids, molecular iodine and potassium hydrogen phosphate resulted in the decarboxylative iodination of coumarin‐3‐carboxylic acids via radical mechanism. Various electron rich and electron poor coumarin‐3‐carboxylic acids were compatible with the established reaction conditions and consequently afforded the corresponding 3‐iodocoumarins in (46–93 %) reaction yields with minimum purification efforts. The formed products serve as valuable precursors to streamline more complex organic compounds incorporating coumarin core.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Decarboxylative Iodination of Coumarin‐3‐carboxylic Acids: A Facile Access to 3‐Iodocoumarins ; day:08 ; month:11 ; year:2024 ; extent:6
Asian journal of organic chemistry ; (08.11.2024) (gesamt 6)

Creator: Thotathil, Vandana
Sidiq, Naheed
Idoudi, Souha
Al‐Zoubi, Raed M.
Shkoor, Mohanad Gh.
Dawoud Bani‐Yaseen, Abdulilah

DOI: 10.1002/ajoc.202400308

URN: urn:nbn:de:101:1-2411091411097.198613133480

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.2025, 7:35 AM CEST

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Thotathil, Vandana
Sidiq, Naheed
Idoudi, Souha
Al‐Zoubi, Raed M.
Shkoor, Mohanad Gh.
Dawoud Bani‐Yaseen, Abdulilah

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Decarboxylative Iodination of Coumarin‐3‐carboxylic Acids: A Facile Access to 3‐Iodocoumarins

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