Type II toxin-antitoxin systems in the unicellular cyanobacterium Synechocystis sp. PCC 6803

Abstract: Bacterial toxin–antitoxin (TA) systems are genetic elements, which are encoded by plasmid as well as chromosomal loci. They mediate plasmid and genomic island maintenance through post-segregational killing mechanisms but may also have milder effects, acting as mobile stress response systems that help certain cells of a population in persisting adverse growth conditions. Very few cyanobacterial TA system have been characterized thus far. In this work, we focus on the cyanobacterium Synechocystis 6803, a widely used model organism. We expand the number of putative Type II TA systems from 36 to 69 plus seven stand-alone components. Forty-seven TA pairs are located on the chromosome and 22 are plasmid-located. Different types of toxins are associated with various antitoxins in a mix and match principle. According to protein domains and experimental data, 81% of all toxins in Synechocystis 6803 likely exhibit RNase activity, suggesting extensive potential for toxicity-related RNA degradation and toxin-mediated transcriptome remodeling. Of particular interest is the Ssr8013–Slr8014 system encoded on plasmid pSYSG, which is part of a larger defense island or the pSYSX system Slr6056–Slr6057, which is linked to a bacterial ubiquitin-like system. Consequently, Synechocystis 6803 is one of the most prolific sources of new information about these genetic elements

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch
Notes
Toxins. 8, 7 (2016), 228, DOI 10.3390/toxins8070228, issn: 2072-6651
IN COPYRIGHT http://rightsstatements.org/page/InC/1.0 rs

Classification
Biowissenschaften, Biologie
Keyword
Toxin
Cyanobakterien
Hydrogenasen
RNS
Antitoxin

Event
Veröffentlichung
(where)
Freiburg
(who)
Universität
(when)
2016
Creator
Kopfmann, Stefan
Rösch, Stefanie K.
Hess, Wolfgang

DOI
10.3390/toxins8070228
URN
urn:nbn:de:bsz:25-freidok-132146
Rights
Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
25.03.2025, 1:51 PM CET

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Time of origin

  • 2016

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