Discovery of an L‐like Configuration for 3’‐Fluoro‐5’‐norcarbonucleoside Phosphonates as Potent Anti‐HIV Agents
Abstract: Recently, we reported the racemic synthesis of 3’‐fluoro‐5’‐norcarbocyclic nucleoside phosphonates bearing adenine as the heterocyclic base. For this study, to evaluate the antiviral activity of each enantiomer, we synthesized both enantiomers, as well as their corresponding bis (POM) prodrugs. Anti‐HIV‐1 evaluation against the LAI strain and clinically NRTI‐resistant HIV‐1 strains are presented. The activities against these different strains show that the activities of bis (POM) prodrug (−)‐9 are equivalent or even superior to those of (R)‐PMPA.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Discovery of an L‐like Configuration for 3’‐Fluoro‐5’‐norcarbonucleoside Phosphonates as Potent Anti‐HIV Agents ; day:15 ; month:09 ; year:2022 ; extent:1
ChemMedChem ; (15.09.2022) (gesamt 1)
- Urheber
-
Geant, Pierre‐Yves
Kaci, Malika
Uttaro, Jean‐Pierre
Périgaud, Christian
Mathé, Christophe
- DOI
-
10.1002/cmdc.202200377
- URN
-
urn:nbn:de:101:1-2022091615110164121114
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:29 MESZ
Datenpartner
Dieses Objekt wird bereitgestellt von:
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Geant, Pierre‐Yves
- Kaci, Malika
- Uttaro, Jean‐Pierre
- Périgaud, Christian
- Mathé, Christophe
Ähnliche Objekte (12)
Human semen contains exosomes with potent anti-HIV-1 activity
Potent Anti‐HIV Activity of Alkyl‐Modified Di PP ro‐Nucleotides
A plant-biotechnology approach for producing highly potent anti-HIV antibodies for antiretroviral therapy consideration
HbAHP-25, a peptide designed in silico, exhibits potent anti-HIV activity in vitro
Characterisation of a highly potent and near pan-neutralising anti-HIV monoclonal antibody expressed in tobacco plants
Targeted Fluoro Positioning for the Discovery of a Potent and Highly Selective Matrix Metalloproteinase Inhibitor
A third generation of radical fluorinating agents based on N-fluoro-N-arylsulfonamides
Synthesis of fluoro-rich pyrimidine-5-carbonitriles as antitubercular agents against H37Rv receptor
Model-based anti-HIV therapy
SYNTHESIS OF SOME NOVEL PYRAZOLINES AS BIOLOGICALLY POTENT AGENTS
Dual anti-HIV mechanism of clofarabine
Universal access to anti-HIV therapy
Human semen contains exosomes with potent anti-HIV-1 activity
Potent Anti‐HIV Activity of Alkyl‐Modified Di PP ro‐Nucleotides
A plant-biotechnology approach for producing highly potent anti-HIV antibodies for antiretroviral therapy consideration
HbAHP-25, a peptide designed in silico, exhibits potent anti-HIV activity in vitro
Characterisation of a highly potent and near pan-neutralising anti-HIV monoclonal antibody expressed in tobacco plants
Targeted Fluoro Positioning for the Discovery of a Potent and Highly Selective Matrix Metalloproteinase Inhibitor
A third generation of radical fluorinating agents based on N-fluoro-N-arylsulfonamides
Synthesis of fluoro-rich pyrimidine-5-carbonitriles as antitubercular agents against H37Rv receptor
Model-based anti-HIV therapy
SYNTHESIS OF SOME NOVEL PYRAZOLINES AS BIOLOGICALLY POTENT AGENTS
Dual anti-HIV mechanism of clofarabine
Universal access to anti-HIV therapy
Human semen contains exosomes with potent anti-HIV-1 activity
Potent Anti‐HIV Activity of Alkyl‐Modified Di PP ro‐Nucleotides
A plant-biotechnology approach for producing highly potent anti-HIV antibodies for antiretroviral therapy consideration
HbAHP-25, a peptide designed in silico, exhibits potent anti-HIV activity in vitro
Characterisation of a highly potent and near pan-neutralising anti-HIV monoclonal antibody expressed in tobacco plants
Targeted Fluoro Positioning for the Discovery of a Potent and Highly Selective Matrix Metalloproteinase Inhibitor
A third generation of radical fluorinating agents based on N-fluoro-N-arylsulfonamides
Synthesis of fluoro-rich pyrimidine-5-carbonitriles as antitubercular agents against H37Rv receptor
Model-based anti-HIV therapy
SYNTHESIS OF SOME NOVEL PYRAZOLINES AS BIOLOGICALLY POTENT AGENTS
Dual anti-HIV mechanism of clofarabine