Discovery of an L‐like Configuration for 3’‐Fluoro‐5’‐norcarbonucleoside Phosphonates as Potent Anti‐HIV Agents

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Abstract: Recently, we reported the racemic synthesis of 3’‐fluoro‐5’‐norcarbocyclic nucleoside phosphonates bearing adenine as the heterocyclic base. For this study, to evaluate the antiviral activity of each enantiomer, we synthesized both enantiomers, as well as their corresponding bis (POM) prodrugs. Anti‐HIV‐1 evaluation against the LAI strain and clinically NRTI‐resistant HIV‐1 strains are presented. The activities against these different strains show that the activities of bis (POM) prodrug (−)‐9 are equivalent or even superior to those of (R)‐PMPA.

Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: Online-Ressource

Language: Englisch

Bibliographic citation: Discovery of an L‐like Configuration for 3’‐Fluoro‐5’‐norcarbonucleoside Phosphonates as Potent Anti‐HIV Agents ; day:15 ; month:09 ; year:2022 ; extent:1
ChemMedChem ; (15.09.2022) (gesamt 1)

Creator: Geant, Pierre‐Yves
Kaci, Malika
Uttaro, Jean‐Pierre
Périgaud, Christian
Mathé, Christophe

DOI: 10.1002/cmdc.202200377

URN: urn:nbn:de:101:1-2022091615110164121114

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 15.08.0009, 8:29 AM CET

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Geant, Pierre‐Yves
Kaci, Malika
Uttaro, Jean‐Pierre
Périgaud, Christian
Mathé, Christophe

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Discovery of an L‐like Configuration for 3’‐Fluoro‐5’‐norcarbonucleoside Phosphonates as Potent Anti‐HIV Agents

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Other Objects (12)

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