Microglia regulate central nervous system myelin growth and integrity
Abstract: Myelin is required for the function of neuronal axons in the central nervous system, but the mechanisms that support myelin health are unclear. Although macrophages in the central nervous system have been implicated in myelin health, it is unknown which macrophage populations are involved and which aspects they influence. Here we show that resident microglia are crucial for the maintenance of myelin health in adulthood in both mice and humans. We demonstrate that microglia are dispensable for developmental myelin ensheathment. However, they are required for subsequent regulation of myelin growth and associated cognitive function, and for preservation of myelin integrity by preventing its degeneration. We show that loss of myelin health due to the absence of microglia is associated with the appearance of a myelinating oligodendrocyte state with altered lipid metabolism. Moreover, this mechanism is regulated through disruption of the TGFβ1–TGFβR1 axis. Our findings highlight microglia as promising therapeutic targets for conditions in which myelin growth and integrity are dysregulated, such as in ageing and neurodegenerative disease
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Anmerkungen
-
Nature. - 613, 7942 (2023) , 120-129, ISSN: 1476-4687
- Ereignis
-
Veröffentlichung
- (wo)
-
Freiburg
- (wer)
-
Universität
- (wann)
-
2022
- Urheber
- DOI
-
10.1038/s41586-022-05534-y
- URN
-
urn:nbn:de:bsz:25-freidok-2322457
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:35 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- McNamara, Niamh B.
- Amann, Lukas
- Prinz, Marco
- Priller, Josef
- Miron, Veronique E.
- Universität
Entstanden
- 2022
Ähnliche Objekte (12)
Author correction: Microglia regulate central nervous system myelin growth and integrity
Microglia regulate central nervous system myelin growth and integrity
Morphometrie und Ontogenese von Interneuronen des Gyrus praecentralis peri- und postnataler Entwicklungsstufen des Menschen
Microglia: same same, but different
Life and death of microglia: Mechanisms governing microglial states and fates
Microglia out of place—mapping macrophages across the developing human body
Microglia out of place—mapping macrophages across the developing human body
The roles of microglia in viral encephalitis: from sensome to therapeutic targeting
Somatic mosaicism in microglia - a model for neurodegeneration in histiocytosis and implications for treatment
Microglia heterogeneity in the single-cell era
Immune checkpoint inhibitor induced neurocognitive deficits in patients
NF-[kappa] B signaling regulates myelination in the CNS
Author correction: Microglia regulate central nervous system myelin growth and integrity
Microglia regulate central nervous system myelin growth and integrity
Morphometrie und Ontogenese von Interneuronen des Gyrus praecentralis peri- und postnataler Entwicklungsstufen des Menschen
Microglia: same same, but different
Life and death of microglia: Mechanisms governing microglial states and fates
Microglia out of place—mapping macrophages across the developing human body
Microglia out of place—mapping macrophages across the developing human body
The roles of microglia in viral encephalitis: from sensome to therapeutic targeting
Somatic mosaicism in microglia - a model for neurodegeneration in histiocytosis and implications for treatment
Microglia heterogeneity in the single-cell era
Immune checkpoint inhibitor induced neurocognitive deficits in patients
NF-[kappa] B signaling regulates myelination in the CNS
Author correction: Microglia regulate central nervous system myelin growth and integrity
Microglia regulate central nervous system myelin growth and integrity
Morphometrie und Ontogenese von Interneuronen des Gyrus praecentralis peri- und postnataler Entwicklungsstufen des Menschen
Microglia: same same, but different
Life and death of microglia: Mechanisms governing microglial states and fates
Microglia out of place—mapping macrophages across the developing human body
Microglia out of place—mapping macrophages across the developing human body
The roles of microglia in viral encephalitis: from sensome to therapeutic targeting
Somatic mosaicism in microglia - a model for neurodegeneration in histiocytosis and implications for treatment
Microglia heterogeneity in the single-cell era
Immune checkpoint inhibitor induced neurocognitive deficits in patients