What does FEXI measure?

Abstract: Filter-exchange imaging (FEXI) has already been utilized in several biomedical studies for evaluating the permeability of cell membranes. The method relies on suppressing the extracellular signal using strong diffusion weighting (the mobility filter causing a reduction in the overall diffusivity) and monitoring the subsequent diffusivity recovery. Using Monte Carlo (MC) simulations, we demonstrate that FEXI is not uniquely sensitive to the transcytolemmal exchange but also to the geometry of involved compartments: Complex geometry offers locations where spins remain unaffected by the mobility filter; moving to other locations afterward, such spins contribute to the diffusivity recovery without actually permeating any membrane. This exchange mechanism warns those who aim to use FEXI in complex media such as brain gray matter and opens large room for investigation towards crystallizing the genuine membrane permeation and characterizing the compartment geometry

Location
Deutsche Nationalbibliothek Frankfurt am Main
Extent
Online-Ressource
Language
Englisch
Notes
NMR in biomedicine. - 35, 12 (2022) , e4804, ISSN: 1099-1492

Event
Veröffentlichung
(where)
Freiburg
(who)
Universität
(when)
2022
Creator
Khateri, Mohammad
Reisert, Marco
Sierra, Alejandra
Tohka, Jussi
Kiselev, Valerij G.

DOI
10.1002/nbm.4804
URN
urn:nbn:de:bsz:25-freidok-2290659
Rights
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
Last update
25.03.2025, 1:46 PM CET

Data provider

This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.

Associated

Time of origin

  • 2022

Other Objects (12)