Enzyme‐Activatable Near‐Infrared Hemicyanines as Modular Scaffolds for in vivo Photodynamic Therapy
Abstract: Photodynamic therapy is an anti‐cancer treatment that requires illumination of photosensitizers to induce local cell death. Current near‐infrared organic photosensitizers are built from large and non‐modular structures that cannot be tuned to improve safety and minimize off‐target toxicity. This work describes a novel chemical platform to generate enzyme‐activatable near‐infrared photosensitizers. We optimized the Se‐bridged hemicyanine scaffold to include caging groups and biocompatible moieties, and generated cathepsin‐triggered photosensitizers for effective ablation of human glioblastoma cells. Furthermore, we demonstrated that enzyme‐activatable Se‐bridged hemicyanines are effective photosensitizers for the safe ablation of microtumors in vivo, creating new avenues in the chemical design of targeted anti‐cancer photodynamic therapy agents.
- Location
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Deutsche Nationalbibliothek Frankfurt am Main
- Extent
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Online-Ressource
- Language
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Englisch
- Bibliographic citation
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Enzyme‐Activatable Near‐Infrared Hemicyanines as Modular Scaffolds for in vivo Photodynamic Therapy ; day:19 ; month:06 ; year:2024 ; extent:7
Angewandte Chemie / International edition. International edition ; (19.06.2024) (gesamt 7)
- Creator
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Cheng, Zhiming
Benson, Sam
Mendive‐Tapia, Lorena
Nestoros, Eleni
Lochenie, Charles
Seah, Deborah
Chang, Kai Yee
Feng, Yi
Vendrell, Marc
- DOI
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10.1002/anie.202404587
- URN
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urn:nbn:de:101:1-2406201423494.026087609982
- Rights
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
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14.08.2025, 11:01 AM CEST
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Associated
- Cheng, Zhiming
- Benson, Sam
- Mendive‐Tapia, Lorena
- Nestoros, Eleni
- Lochenie, Charles
- Seah, Deborah
- Chang, Kai Yee
- Feng, Yi
- Vendrell, Marc
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Coexistent of paradoxical herniation and subdural hygroma: a case report
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