Molecular basis and clonal evolution of myeloproliferative neoplasms
Abstract: Myeloproliferative neoplasms (MPNs) represent a group of diseases that affect the myeloid lineage, characterized by the presence of an excess of terminally differentiated myeloid cells. Defects causing clonal hematopoiesis are a key factor in the emergence of these diseases. Throughout the years, a number of causative defects have been identified, predominantly affecting cytokine signaling and gene expression regulation. This review aims to provide an update on the current status of the MPN field in relation to identification of molecular defects involved in the disease and its clonal evolution.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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Molecular basis and clonal evolution of myeloproliferative neoplasms ; volume:51 ; number:10 ; year:2013 ; pages:1889-1896 ; extent:8
Clinical chemistry and laboratory medicine ; 51, Heft 10 (2013), 1889-1896 (gesamt 8)
- Urheber
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Cleary, Ciara
Kralovics, Robert
- DOI
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10.1515/cclm-2013-0135
- URN
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urn:nbn:de:101:1-2022061115121722551672
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:38 MESZ
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Beteiligte
- Cleary, Ciara
- Kralovics, Robert
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