Arteriopathy in pediatric stroke: an underestimated clinical entity

Abstract: Background: Pediatric arterial ischemic stroke (AIS), which was thought to be a rare disorder, is being increasingly recognized as an important cause of neurological morbidity, thanks to new advances in neuroimaging. Objective: The aim of this study was to review the main etiologies of stroke due to arteriopathy in children. Methods: Using a series of cases from our institution, we addressed its epidemiological aspects, physiopathology, imaging findings from CT, MR angiography, MR conventional sequences and MR DWI, and nuclear medicine findings. Results: Through discussion of the most recent classification for childhood AIS (Childhood AIS Standardized Classification and Diagnostic Evaluation, CASCADE), we propose a modified classification based on the anatomical site of disease, which includes vasculitis, varicella, arterial dissection, moyamoya, fibromuscular dysplasia, Takayasu's arteritis and genetic causes (such as ACTA-2 mutation, PHACE syndrome and ADA-2 deficiency). We have detailed each of these separately. Conclusions: Prompt recognition of AIS and thorough investigation for potential risk factors are crucial for a better outcome. In this scenario, neurovascular imaging plays an important role in diagnosing AIS and identifying children at high risk of recurrent stroke.

Object Details

• Alternative title: Arteriopatia em crianças com acidente vascular cerebral: uma entidade clínica subestimada
• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Arteriopathy in pediatric stroke: an underestimated clinical entity ; volume:79 ; number:04 ; year:2021 ; pages:321-333 ; Arquivos de neuro-psiquiatria ; 79, Heft 04 (2021), 321-333

Contributors, Places and Time

• Contributor: PIZZATTO, Ronaldo ; RESENDE, Lucas Lopes ; LOBO, Carlos Felipe Teixeira ; NEVES, Yuri Costa Sarno ; PAZ, José Albino da ; ALVES, César Augusto Pinheiro Ferreira ; LEITE, Claudia da Costa ; LUCATO, Leandro Tavares

Further information

• DOI: 10.1590/0004-282X-ANP-2020-0105
• URN: urn:nbn:de:101:1-2023072010451886541627
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 14.08.2025, 10:56 AM CEST