Synthesis and biological evaluation of 4-(2′,4′-difluorobiphenyl-4-yl)-6-arylpyrimidin- 2-amine derivatives
Abstract: 4-(2′,4′-Difluorobiphenyl-4-yl)-6-arylpyrimidin-2-amines 5a–g were synthesized and evaluated for their ability to inhibit various bacterial and fungal strains. The cytotoxicity of the compounds was investigated by a 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay against the Hep-2 cell line. Molecular docking studies were also conducted to locate the binding interaction with the target protein 4LRH.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Synthesis and biological evaluation of 4-(2′,4′-difluorobiphenyl-4-yl)-6-arylpyrimidin- 2-amine derivatives ; volume:22 ; number:6 ; year:2016 ; pages:351-356 ; extent:6
Heterocyclic communications ; 22, Heft 6 (2016), 351-356 (gesamt 6)
- Creator
-
Fathimunnisa, M.
Manikandan, Haridoss
Neelakandan, K.
Rajendra Prasad, N.
Ganesan, M.
- DOI
-
10.1515/hc-2016-0050
- URN
-
urn:nbn:de:101:1-2501130557355.907183165721
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:28 AM CEST
Data provider
This object is provided by:
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Fathimunnisa, M.
- Manikandan, Haridoss
- Neelakandan, K.
- Rajendra Prasad, N.
- Ganesan, M.
Other Objects (12)
Biological activity of 3-(2-benzoxazol-5-yl)alanine derivatives
![Benzo[c][2,7]naphthyridin-5-yl-amine und Benzo[h][1,6]naphthyridin-5-yl-amine](/assets/placeholder/searchResultMediaNoDigitisedMedia.png)
Benzo[c][2,7]naphthyridin-5-yl-amine und Benzo[h][1,6]naphthyridin-5-yl-amine
Benzo[c][2,7]naphthyridin-5-yl-amine und Benzo[h][1,6]naphthyridin-5-yl-amine
Pyrido[3,2-b]indol-4-yl-amine, [1]Benzofuro[3,2-b]pyridin-4-yl-amine und [1]Benzothienol[3,2-b]pyridin-4-yl-amine : Darstellung von Antimalariamitteln
Design, synthesis and biological evaluation of 3-(2-aminooxazol-5-yl)-2H-chromen-2-one derivatives
Microwave-assisted synthesis of bis (N -substituted thiazol-2-amine) derivatives and their biological activities
Indeno[1,2-b]pyridin-4-yl-amine und Indeno[1,2-d]pyrimidin-4-yl-amine : Darstellung und Prüfung auf antimikrobielle Wirksamkeit, sowie gegen Malaria
4-(4-Bromophenyl)-thiazol-2-amine derivatives: synthesis, biological activity and molecular docking study with ADME profile
Synthesis, molecular docking and biological potentials of new 2-(4-(2-chloroacetyl) piperazin-1-yl)-N-(2-(4-chlorophenyl)-4-oxoquinazolin-3(4H)-yl)acetamide derivatives
Gegen Malaria wirksame 10H-Indolo[3,2-b]chinolin-11-yl-amine
Design, Synthesis and Biological Evaluation of N -((2-phenyloxazol-4-yl) methyl) Pyrimidine Carboxamide Derivatives as Potential Fungicidal Agents
In silico evaluation of some 4-(quinolin-2-yl)pyrimidin-2-amine derivatives as potent V600E-BRAF inhibitors with pharmacokinetics ADMET and drug-likeness predictions
Biological activity of 3-(2-benzoxazol-5-yl)alanine derivatives
Benzo[c][2,7]naphthyridin-5-yl-amine und Benzo[h][1,6]naphthyridin-5-yl-amine
Benzo[c][2,7]naphthyridin-5-yl-amine und Benzo[h][1,6]naphthyridin-5-yl-amine
Pyrido[3,2-b]indol-4-yl-amine, [1]Benzofuro[3,2-b]pyridin-4-yl-amine und [1]Benzothienol[3,2-b]pyridin-4-yl-amine : Darstellung von Antimalariamitteln
Design, synthesis and biological evaluation of 3-(2-aminooxazol-5-yl)-2H-chromen-2-one derivatives
Microwave-assisted synthesis of bis (N -substituted thiazol-2-amine) derivatives and their biological activities
Indeno[1,2-b]pyridin-4-yl-amine und Indeno[1,2-d]pyrimidin-4-yl-amine : Darstellung und Prüfung auf antimikrobielle Wirksamkeit, sowie gegen Malaria
4-(4-Bromophenyl)-thiazol-2-amine derivatives: synthesis, biological activity and molecular docking study with ADME profile
Synthesis, molecular docking and biological potentials of new 2-(4-(2-chloroacetyl) piperazin-1-yl)-N-(2-(4-chlorophenyl)-4-oxoquinazolin-3(4H)-yl)acetamide derivatives
Gegen Malaria wirksame 10H-Indolo[3,2-b]chinolin-11-yl-amine
Design, Synthesis and Biological Evaluation of N -((2-phenyloxazol-4-yl) methyl) Pyrimidine Carboxamide Derivatives as Potential Fungicidal Agents
In silico evaluation of some 4-(quinolin-2-yl)pyrimidin-2-amine derivatives as potent V600E-BRAF inhibitors with pharmacokinetics ADMET and drug-likeness predictions
Biological activity of 3-(2-benzoxazol-5-yl)alanine derivatives
Benzo[c][2,7]naphthyridin-5-yl-amine und Benzo[h][1,6]naphthyridin-5-yl-amine
Benzo[c][2,7]naphthyridin-5-yl-amine und Benzo[h][1,6]naphthyridin-5-yl-amine
Pyrido[3,2-b]indol-4-yl-amine, [1]Benzofuro[3,2-b]pyridin-4-yl-amine und [1]Benzothienol[3,2-b]pyridin-4-yl-amine : Darstellung von Antimalariamitteln
Design, synthesis and biological evaluation of 3-(2-aminooxazol-5-yl)-2H-chromen-2-one derivatives
Microwave-assisted synthesis of bis (N -substituted thiazol-2-amine) derivatives and their biological activities
Indeno[1,2-b]pyridin-4-yl-amine und Indeno[1,2-d]pyrimidin-4-yl-amine : Darstellung und Prüfung auf antimikrobielle Wirksamkeit, sowie gegen Malaria
4-(4-Bromophenyl)-thiazol-2-amine derivatives: synthesis, biological activity and molecular docking study with ADME profile
Synthesis, molecular docking and biological potentials of new 2-(4-(2-chloroacetyl) piperazin-1-yl)-N-(2-(4-chlorophenyl)-4-oxoquinazolin-3(4H)-yl)acetamide derivatives
Gegen Malaria wirksame 10H-Indolo[3,2-b]chinolin-11-yl-amine
Design, Synthesis and Biological Evaluation of N -((2-phenyloxazol-4-yl) methyl) Pyrimidine Carboxamide Derivatives as Potential Fungicidal Agents