Prognostic value of total thiol and D-dimer in patients hospitalized with COVID-19

Objectives: The lack of specific treatment for COVID-19 and the fact that the clinical course differs between individuals makes it difficult to predict the prognosis. The aim was to investigate the prognostic value of total thiol, D-dimer, procalcitonin (PCT), ischemia-modified albumin (IMA), and complete blood count (CBC) in patients hospitalized with COVID-19. Methods: 100 consecutive patients were hospitalized with COVID-19, confirmed by RT-PCR between December 2021-March 2022 and 30 healthy control participated in the study. According to the World Health Organization guideline, two groups were created as critical and non-critical. D-dimer, PCT, IMA, total thiol levels, and CBC were analyzed. Receiver-operating characteristic curves (ROC) were utilized to determine an optimum cut-off value for distinction. Results: We defined a cut-off value of 1,030 μg/L for D-dimer (Area Under Curve, AUC): 0.691; p=0.001) and 148 μmol/L for total thiol (AUC: 0.749; p<0.001) via ROC analysis. The combination of D-dimer and total thiol reached 65% positive predictive value (PPV) and 80% negative predictive value (NPV). Conclusions: D-dimer and total thiol may help predict critical patients with COVID-19.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Prognostic value of total thiol and D-dimer in patients hospitalized with COVID-19 ; volume:48 ; number:2 ; year:2023 ; pages:209-214 ; extent:06 ; Turkish journal of biochemistry ; 48, Heft 2 (2023), 209-214 (gesamt 06)

Beteiligte, Orts- und Zeitangaben

• Urheber: Barlak Keti, Didem ; Muhtaroglu, Sabahattin ; Yildiz, Orhan ; Saraçoglu, Hatice

Weitere Informationen

• DOI: 10.1515/tjb-2022-0171
• URN: urn:nbn:de:101:1-2023042914061170428422
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 14.08.2025, 10:50 MESZ