A case of falsely elevated D-dimer result
Objectives: Heterophile antibodies can cause interferences in immunometric assays. While many tests are shown to be affected by interference from heterophilic antibodies, the D-dimer test has rarely been reported to be affected. With this case, we report an elevated D-dimer measurement which was not compatible with the clinical presentation. Case presentation: A 41-year-old patient who was admitted to hospital with heart palpitations had a D-dimer elevation irrelevant to his clinical condition. D-dimer measurements were repeated in new samples directly and after being treated in heterophilic blocking tube with two different reagent lots of a latex-based automated immunoturbidimetric assay and an immunoturbidometric assay. D-dimer values were normalized (0–0.5 mg/L) when we used a new lot of reagent on the same instrument or measured by an immunoturbidometric method on the chemistry analyzer. After treatment with HBT, all samples revealed D-dimer results within the reference ranges. Conclusions: The presence of heterophile antibodies in a sample should be considered when an elevated D-dimer value that is not compatible with the clinical presentation is encountered. Apart from the patient’s HA’s causing false results, sporadic susceptibility of the reagents should also be kept in mind as a possibility.
- Standort
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Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
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Online-Ressource
- Sprache
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Englisch
- Erschienen in
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A case of falsely elevated D-dimer result ; volume:47 ; number:5 ; year:2022 ; pages:686-689 ; extent:04
Turkish journal of biochemistry ; 47, Heft 5 (2022), 686-689 (gesamt 04)
- Urheber
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Çevlik, Tülay
Turkal, Rana
Haklar, Goncagül
Şirikçi, Önder
- DOI
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10.1515/tjb-2021-0262
- URN
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urn:nbn:de:101:1-2022103013021073840805
- Rechteinformation
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Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
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15.08.2025, 07:35 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Çevlik, Tülay
- Turkal, Rana
- Haklar, Goncagül
- Şirikçi, Önder
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