Minimally Invasive Syringe‐Injectable Hydrogel with Angiogenic Factors for Ischemic Stroke Treatment

Abstract: Ischemic stroke (IS) accounts for most stroke incidents and causes intractable damage to brain tissue. This condition manifests as diverse aftereffects, such as motor impairment, emotional disturbances, and dementia. However, a fundamental approach to curing IS remains unclear. This study proposes a novel approach for treating IS by employing minimally invasive and injectable jammed gelatin‐norbornene nanofibrous hydrogels (GNF) infused with growth factors (GFs). The developed GNF/GF hydrogels are administered to the motor cortex of a rat IS model to evaluate their therapeutic effects on IS‐induced motor dysfunction. GNFs mimic a natural fibrous extracellular matrix architecture and can be precisely injected into a targeted brain area. The syringe‐injectable jammed nanofibrous hydrogel system increased angiogenesis, inflammation, and sensorimotor function in the IS‐affected brain. For clinical applications, the biocompatible GNF hydrogel has the potential to efficiently load disease‐specific drugs, enabling targeted therapy for treating a wide range of neurological diseases.

Object Details

• Location: Deutsche Nationalbibliothek Frankfurt am Main
• Extent: Online-Ressource
• Language: Englisch

References and Relationships

• Bibliographic citation: Minimally Invasive Syringe‐Injectable Hydrogel with Angiogenic Factors for Ischemic Stroke Treatment ; day:09 ; month:11 ; year:2024 ; extent:13 ; Advanced healthcare materials ; (09.11.2024) (gesamt 13)

Contributors, Places and Time

• Creator: Kim, Donggue ; Lee, Ji Woo ; Kim, Yang Tae ; Choe, Junhyeok ; Kim, Gaeun ; Ha, Chang Man ; Kim, Jae Geun ; Song, Kwang Hoon ; Yang, Sunggu

Further information

• DOI: 10.1002/adhm.202403119
• URN: urn:nbn:de:101:1-2411101330369.929883303035
• Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Last update: 15.08.2025, 7:32 AM CEST