Minimally Invasive Syringe‐Injectable Hydrogel with Angiogenic Factors for Ischemic Stroke Treatment
Abstract: Ischemic stroke (IS) accounts for most stroke incidents and causes intractable damage to brain tissue. This condition manifests as diverse aftereffects, such as motor impairment, emotional disturbances, and dementia. However, a fundamental approach to curing IS remains unclear. This study proposes a novel approach for treating IS by employing minimally invasive and injectable jammed gelatin‐norbornene nanofibrous hydrogels (GNF) infused with growth factors (GFs). The developed GNF/GF hydrogels are administered to the motor cortex of a rat IS model to evaluate their therapeutic effects on IS‐induced motor dysfunction. GNFs mimic a natural fibrous extracellular matrix architecture and can be precisely injected into a targeted brain area. The syringe‐injectable jammed nanofibrous hydrogel system increased angiogenesis, inflammation, and sensorimotor function in the IS‐affected brain. For clinical applications, the biocompatible GNF hydrogel has the potential to efficiently load disease‐specific drugs, enabling targeted therapy for treating a wide range of neurological diseases.
- Standort
-
Deutsche Nationalbibliothek Frankfurt am Main
- Umfang
-
Online-Ressource
- Sprache
-
Englisch
- Erschienen in
-
Minimally Invasive Syringe‐Injectable Hydrogel with Angiogenic Factors for Ischemic Stroke Treatment ; day:09 ; month:11 ; year:2024 ; extent:13
Advanced healthcare materials ; (09.11.2024) (gesamt 13)
- Urheber
-
Kim, Donggue
Lee, Ji Woo
Kim, Yang Tae
Choe, Junhyeok
Kim, Gaeun
Ha, Chang Man
Kim, Jae Geun
Song, Kwang Hoon
Yang, Sunggu
- DOI
-
10.1002/adhm.202403119
- URN
-
urn:nbn:de:101:1-2411101330369.929883303035
- Rechteinformation
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Letzte Aktualisierung
-
15.08.2025, 07:32 MESZ
Datenpartner
Deutsche Nationalbibliothek. Bei Fragen zum Objekt wenden Sie sich bitte an den Datenpartner.
Beteiligte
- Kim, Donggue
- Lee, Ji Woo
- Kim, Yang Tae
- Choe, Junhyeok
- Kim, Gaeun
- Ha, Chang Man
- Kim, Jae Geun
- Song, Kwang Hoon
- Yang, Sunggu
Ähnliche Objekte (12)
An injectable self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic skin wound repair
Molecular Syringe for Cargo Photorelease: Red‐Light‐Triggered Supramolecular Hydrogel
Highly-stable, injectable, conductive hydrogel for chronic neuromodulation
Thermoresponsive and Injectable Hydrogel for Tissue Agnostic Regeneration
Injectable and biodegradable piezoelectric hydrogel for osteoarthritis treatment
Injectable bone cement based on magnesium potassium phosphate and cross-linked alginate hydrogel designed for minimally invasive orthopedic procedures
Gemcitabine‐Loaded Injectable Hydrogel for Localized Breast Cancer Immunotherapy
Syringe
Injectable hyaluronic-acid-doxycycline hydrogel therapy in experimental rabbit osteoarthritis
Injectable hydrogel electrodes as conduction highways to restore native pacing
Self‐Healing and Injectable Hydrogel for Matching Skin Flap Regeneration
Injectable 2D Material‐Based Sensor Array for Minimally Invasive Neural Implants
An injectable self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic skin wound repair
Molecular Syringe for Cargo Photorelease: Red‐Light‐Triggered Supramolecular Hydrogel
Highly-stable, injectable, conductive hydrogel for chronic neuromodulation
Thermoresponsive and Injectable Hydrogel for Tissue Agnostic Regeneration
Injectable and biodegradable piezoelectric hydrogel for osteoarthritis treatment
Injectable bone cement based on magnesium potassium phosphate and cross-linked alginate hydrogel designed for minimally invasive orthopedic procedures
Gemcitabine‐Loaded Injectable Hydrogel for Localized Breast Cancer Immunotherapy
Syringe
Injectable hyaluronic-acid-doxycycline hydrogel therapy in experimental rabbit osteoarthritis
Injectable hydrogel electrodes as conduction highways to restore native pacing
Self‐Healing and Injectable Hydrogel for Matching Skin Flap Regeneration
Injectable 2D Material‐Based Sensor Array for Minimally Invasive Neural Implants
An injectable self-healing coordinative hydrogel with antibacterial and angiogenic properties for diabetic skin wound repair
Molecular Syringe for Cargo Photorelease: Red‐Light‐Triggered Supramolecular Hydrogel
Highly-stable, injectable, conductive hydrogel for chronic neuromodulation
Thermoresponsive and Injectable Hydrogel for Tissue Agnostic Regeneration
Injectable and biodegradable piezoelectric hydrogel for osteoarthritis treatment
Injectable bone cement based on magnesium potassium phosphate and cross-linked alginate hydrogel designed for minimally invasive orthopedic procedures
Gemcitabine‐Loaded Injectable Hydrogel for Localized Breast Cancer Immunotherapy
Syringe
Injectable hyaluronic-acid-doxycycline hydrogel therapy in experimental rabbit osteoarthritis
Injectable hydrogel electrodes as conduction highways to restore native pacing
Self‐Healing and Injectable Hydrogel for Matching Skin Flap Regeneration