Transporting Hydrogel via Chinese Acupuncture Needles for Lesion Positioning Therapy
Abstract: Lesion positioning therapy optimizes medical treatment by directly targeting lesions. However, strong physical barriers greatly hinder its wide use. Here, the Chinese acupuncture needles (CA‐needles) with a screw‐thread structure at the tip (ST‐needle) and the hydrogel with the function of adhesive metal and loaded drug sustained‐release structure are designed, through the minimally invasive and precise positioning of lesions by ST‐needles, the dry‐wet conversion of hydrogel with absorbing fluids and swelling, and the rotation back of ST‐needles, the hydrogel is precisely positioned in the subchondral bone with physical barrier to achieve precise positioning therapy for lesions. In vitro experiments show that the ST‐needle penetrates the physical barrier of cartilage and enters the subchondral bone. Simultaneously, the hydrogel transfer efficiency of the ST‐needle (73.25%) is significantly higher than that of the CA‐needle (29.92%) due to the protective effect of the screw‐thread structure. In vivo experiments demonstrate that precise positioning in subchondral bone in osteoarthritis rats with ST‐needles effectively inhibits abnormal subchondral bone remodeling, alleviating the degeneration and degradation of cartilage. Therefore, ST‐needles achieve lesion positioning therapy through minimally invasive penetration of physical barriers, precisely positioning within lesions, and delivering hydrogel to release drugs.
- Location
-
Deutsche Nationalbibliothek Frankfurt am Main
- Extent
-
Online-Ressource
- Language
-
Englisch
- Bibliographic citation
-
Transporting Hydrogel via Chinese Acupuncture Needles for Lesion Positioning Therapy ; day:11 ; month:04 ; year:2022 ; extent:17
Advanced science ; (11.04.2022) (gesamt 17)
- Creator
- DOI
-
10.1002/advs.202200079
- URN
-
urn:nbn:de:101:1-2022041215465391103137
- Rights
-
Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
- Last update
-
15.08.2025, 7:24 AM CEST
Data provider
Deutsche Nationalbibliothek. If you have any questions about the object, please contact the data provider.
Associated
- Lin, Feng
- Wang, Zhen
- Xiang, Lei
- Wu, Longxi
- Liu, Yupu
- Xi, Xiaobing
- Deng, Lianfu
- Cui, Wenguo
Other Objects (12)
Correction to “Transporting Hydrogel via Chinese Acupuncture Needles for Lesion Positioning Therapy”
Molecular functions of cell plate-associated phosphoinositides during plant somatic cytokinesis
Mechanical Performance and Stress–Strain Relationships for Grouted Splices Under Tensile and Cyclic Loadings
Sustainable Electric Vehicle Batteries for a Sustainable World: Perspectives on Battery Cathodes, Environment, Supply Chain, Manufacturing, Life Cycle, and Policy
Mechanically and Thermally Robust Gel Electrolytes Built from A Charged Double Helical Polymer
Interpretation of course conceptual structure and student self-efficacy: an integrated strategy of knowledge graphs with item response modeling
An optimal control theory approach to non-pharmaceutical interventions
In silico modelling of hormone response elements
Modeling and Simulation of Bulk Metallic Glass Crystallization During Laser Powder Bed Fusion
High Performance Perovskite Solar Cells
Activity limitation and participation restriction in Osteoarthritis and Rheumatoid arthritis: findings based on the National Health and Nutritional Examination Survey
MCtandem: an efficient tool for large-scale peptide identification on many integrated core (MIC) architecture
Correction to “Transporting Hydrogel via Chinese Acupuncture Needles for Lesion Positioning Therapy”
Molecular functions of cell plate-associated phosphoinositides during plant somatic cytokinesis
Mechanical Performance and Stress–Strain Relationships for Grouted Splices Under Tensile and Cyclic Loadings
Sustainable Electric Vehicle Batteries for a Sustainable World: Perspectives on Battery Cathodes, Environment, Supply Chain, Manufacturing, Life Cycle, and Policy
Mechanically and Thermally Robust Gel Electrolytes Built from A Charged Double Helical Polymer
Interpretation of course conceptual structure and student self-efficacy: an integrated strategy of knowledge graphs with item response modeling
An optimal control theory approach to non-pharmaceutical interventions
In silico modelling of hormone response elements
Modeling and Simulation of Bulk Metallic Glass Crystallization During Laser Powder Bed Fusion
High Performance Perovskite Solar Cells
Activity limitation and participation restriction in Osteoarthritis and Rheumatoid arthritis: findings based on the National Health and Nutritional Examination Survey
MCtandem: an efficient tool for large-scale peptide identification on many integrated core (MIC) architecture
Correction to “Transporting Hydrogel via Chinese Acupuncture Needles for Lesion Positioning Therapy”
Molecular functions of cell plate-associated phosphoinositides during plant somatic cytokinesis
Mechanical Performance and Stress–Strain Relationships for Grouted Splices Under Tensile and Cyclic Loadings
Sustainable Electric Vehicle Batteries for a Sustainable World: Perspectives on Battery Cathodes, Environment, Supply Chain, Manufacturing, Life Cycle, and Policy
Mechanically and Thermally Robust Gel Electrolytes Built from A Charged Double Helical Polymer
Interpretation of course conceptual structure and student self-efficacy: an integrated strategy of knowledge graphs with item response modeling
An optimal control theory approach to non-pharmaceutical interventions
In silico modelling of hormone response elements
Modeling and Simulation of Bulk Metallic Glass Crystallization During Laser Powder Bed Fusion
High Performance Perovskite Solar Cells
Activity limitation and participation restriction in Osteoarthritis and Rheumatoid arthritis: findings based on the National Health and Nutritional Examination Survey