RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS

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Location: Deutsche Nationalbibliothek Frankfurt am Main

Extent: 1 Online-Ressource.

Language: Englisch

Bibliographic citation: RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS ; volume:147 ; number:1 ; day:5 ; month:3 ; year:2024 ; pages:1-15 ; date:6.2024
Acta neuropathologica ; 147, Heft 1 (5.3.2024), 1-15, 6.2024

Creator: Spence, Holly
Waldron, Fergal M.
Saleeb, Rebecca S.
Brown, Anna-Leigh
Rifai, Olivia M.
Gilodi, Martina
Read, Fiona
Roberts, Kristine
Milne, Gillian
Wilkinson, Debbie
O’Shaughnessy, Judi
Pastore, Annalisa
Fratta, Pietro
Shneider, Neil
Tartaglia, Gian Gaetano
Zacco, Elsa
Horrocks, Mathew H.
Gregory, Jenna M.

Contributor: SpringerLink (Online service)

DOI: 10.1007/s00401-024-02705-1

URN: urn:nbn:de:101:1-2405101056496.582598751855

Rights: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.

Last update: 14.08.2025, 11:03 AM CEST

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Associated

Spence, Holly
Waldron, Fergal M.
Saleeb, Rebecca S.
Brown, Anna-Leigh
Rifai, Olivia M.
Gilodi, Martina
Read, Fiona
Roberts, Kristine
Milne, Gillian
Wilkinson, Debbie
O’Shaughnessy, Judi
Pastore, Annalisa
Fratta, Pietro
Shneider, Neil
Tartaglia, Gian Gaetano
Zacco, Elsa
Horrocks, Mathew H.
Gregory, Jenna M.
SpringerLink (Online service)

Other Objects (12)

Quantitative analysis of cryptic splicing associated with TDP-43 depletion

TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic splicing inhibition

Tdp-43 cryptic exons are highly variable between cell types

Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological hallmark of TDP-43-associated Alzheimer’s disease

SUMOylation Regulates TDP-43 Splicing Activity and Nucleocytoplasmic Distribution

HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases

TDP-43-regulated cryptic RNAs accumulate in Alzheimer’s disease brains

Correction: HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases

The N-terminal dimerization is required for TDP-43 splicing activity

Alternatively spliced ELAVL3 cryptic exon 4a causes ELAVL3 downregulation in ALS TDP-43 proteinopathy

Tetracycline aptamer-controlled regulation of pre-mRNA splicing in yeast

Nucleolar stress in C9orf72 and sporadic ALS spinal motor neurons precedes TDP-43 mislocalization

Quantitative analysis of cryptic splicing associated with TDP-43 depletion

TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic splicing inhibition

Tdp-43 cryptic exons are highly variable between cell types

Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological hallmark of TDP-43-associated Alzheimer’s disease

SUMOylation Regulates TDP-43 Splicing Activity and Nucleocytoplasmic Distribution

HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases

TDP-43-regulated cryptic RNAs accumulate in Alzheimer’s disease brains

Correction: HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases

The N-terminal dimerization is required for TDP-43 splicing activity

Alternatively spliced ELAVL3 cryptic exon 4a causes ELAVL3 downregulation in ALS TDP-43 proteinopathy

Tetracycline aptamer-controlled regulation of pre-mRNA splicing in yeast

Nucleolar stress in C9orf72 and sporadic ALS spinal motor neurons precedes TDP-43 mislocalization

Quantitative analysis of cryptic splicing associated with TDP-43 depletion

TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic splicing inhibition

Tdp-43 cryptic exons are highly variable between cell types

Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological hallmark of TDP-43-associated Alzheimer’s disease

SUMOylation Regulates TDP-43 Splicing Activity and Nucleocytoplasmic Distribution

HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases

TDP-43-regulated cryptic RNAs accumulate in Alzheimer’s disease brains

Correction: HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases

The N-terminal dimerization is required for TDP-43 splicing activity

Alternatively spliced ELAVL3 cryptic exon 4a causes ELAVL3 downregulation in ALS TDP-43 proteinopathy

Tetracycline aptamer-controlled regulation of pre-mRNA splicing in yeast

Nucleolar stress in C9orf72 and sporadic ALS spinal motor neurons precedes TDP-43 mislocalization

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RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS

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Other Objects (12)

Quantitative analysis of cryptic splicing associated with TDP-43 depletion

TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic splicing inhibition

Tdp-43 cryptic exons are highly variable between cell types

Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological hallmark of TDP-43-associated Alzheimer’s disease

SUMOylation Regulates TDP-43 Splicing Activity and Nucleocytoplasmic Distribution

HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases

TDP-43-regulated cryptic RNAs accumulate in Alzheimer’s disease brains

Correction: HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases

The N-terminal dimerization is required for TDP-43 splicing activity

Alternatively spliced ELAVL3 cryptic exon 4a causes ELAVL3 downregulation in ALS TDP-43 proteinopathy

Tetracycline aptamer-controlled regulation of pre-mRNA splicing in yeast

Nucleolar stress in C9orf72 and sporadic ALS spinal motor neurons precedes TDP-43 mislocalization

Quantitative analysis of cryptic splicing associated with TDP-43 depletion

TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic splicing inhibition

Tdp-43 cryptic exons are highly variable between cell types

Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological hallmark of TDP-43-associated Alzheimer’s disease

SUMOylation Regulates TDP-43 Splicing Activity and Nucleocytoplasmic Distribution

HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases

TDP-43-regulated cryptic RNAs accumulate in Alzheimer’s disease brains

Correction: HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases

The N-terminal dimerization is required for TDP-43 splicing activity

Alternatively spliced ELAVL3 cryptic exon 4a causes ELAVL3 downregulation in ALS TDP-43 proteinopathy

Tetracycline aptamer-controlled regulation of pre-mRNA splicing in yeast

Nucleolar stress in C9orf72 and sporadic ALS spinal motor neurons precedes TDP-43 mislocalization

Quantitative analysis of cryptic splicing associated with TDP-43 depletion

TDP-43 regulates LC3ylation in neural tissue through ATG4B cryptic splicing inhibition

Tdp-43 cryptic exons are highly variable between cell types

Cryptic splicing of stathmin-2 and UNC13A mRNAs is a pathological hallmark of TDP-43-associated Alzheimer’s disease

SUMOylation Regulates TDP-43 Splicing Activity and Nucleocytoplasmic Distribution

HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases

TDP-43-regulated cryptic RNAs accumulate in Alzheimer’s disease brains

Correction: HDGFL2 cryptic proteins report presence of TDP-43 pathology in neurodegenerative diseases

The N-terminal dimerization is required for TDP-43 splicing activity

Alternatively spliced ELAVL3 cryptic exon 4a causes ELAVL3 downregulation in ALS TDP-43 proteinopathy

Tetracycline aptamer-controlled regulation of pre-mRNA splicing in yeast

Nucleolar stress in C9orf72 and sporadic ALS spinal motor neurons precedes TDP-43 mislocalization

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