Design Parameters of Tissue‐Engineering Scaffolds at the Atomic Scale

Abstract: Stem‐cell behavior is regulated by the material properties of the surrounding extracellular matrix, which has important implications for the design of tissue‐engineering scaffolds. However, our understanding of the material properties of stem‐cell scaffolds is limited to nanoscopic‐to‐macroscopic length scales. Herein, a solid‐state NMR approach is presented that provides atomic‐scale information on complex stem‐cell substrates at near physiological conditions and at natural isotope abundance. Using self‐assembled peptidic scaffolds designed for nervous‐tissue regeneration, we show at atomic scale how scaffold‐assembly degree, mechanics, and homogeneity correlate with favorable stem cell behavior. Integration of solid‐state NMR data with molecular dynamics simulations reveals a highly ordered fibrillar structure as the most favorable stem‐cell scaffold. This could improve the design of tissue‐engineering scaffolds and other self‐assembled biomaterials.

Angaben zum Objekt

• Standort: Deutsche Nationalbibliothek Frankfurt am Main
• Umfang: Online-Ressource
• Sprache: Englisch

Verweise und Beziehungen

• Erschienen in: Design Parameters of Tissue‐Engineering Scaffolds at the Atomic Scale ; volume:58 ; number:47 ; year:2019 ; pages:16943-16951 ; extent:9 ; Angewandte Chemie / International edition. International edition ; 58, Heft 47 (2019), 16943-16951 (gesamt 9)

Beteiligte, Orts- und Zeitangaben

• Urheber: Jekhmane, Shehrazade ; Prachar, Marek ; Pugliese, Raffaele ; Fontana, Federico ; Medeiros‐Silva, João ; Gelain, Fabrizio ; Weingarth, Markus

Weitere Informationen

• DOI: 10.1002/anie.201907880
• URN: urn:nbn:de:101:1-2022071210550932763771
• Rechteinformation: Open Access; Der Zugriff auf das Objekt ist unbeschränkt möglich.
• Letzte Aktualisierung: 15.08.2025, 07:34 MESZ